Bone regeneration in limb lengthening

Janet L. Walker, Simone Battibugli

Research output: Contribution to journalReview articlepeer-review


PURPOSE OF REVIEW: Impaired bone healing is a major source of complications in limb lengthening. This review presents our recent understanding of bone healing biology and basic research for modulating bone healing in limb lengthening. RECENT FINDINGS: Angiogenesis appears to play a major role in distraction osteogenesis with increased gene expression and upregulation of many angiogenic factors during the process. In-vivo and clinical studies have demonstrated the benefits of bone morphogenic protein, bisphosphonates, electromagnetic fields, and ultrasound to aid in bone healing during limb lengthening. SUMMARY: The mechanisms of distraction osteogenesis continue to be studied using in-vivo models. Beneficial effects of growth factors, bisphophonates, electromagnetic fields and ultrasound have been demonstrated to enhance bone healing in in-vivo limb-lengthening models. Further clinical studies are needed to demonstrate their efficacy.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalCurrent Opinion in Orthopaedics
Issue number6
StatePublished - Dec 2006


  • Bisphosphonates
  • Bone morphogenic protein
  • Distraction osteogenesis
  • Electromagnetic fields
  • Ultrasound

ASJC Scopus subject areas

  • Surgery


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