Abstract
Boshramycinones A-C (1–3), three new anthracyclinones, were isolated from the culture broth of the marine-derived Streptomyces sp. Mei 16-1,2 together with 2-acetyl-1,8-dihydroxy-3-methyl-anthraquinone (4) and bafilomycins B1, B2, and C1-amide. The isolated compounds were identified by NMR spectroscopy and mass spectrometry, the absolute configuration of 3 was determined by comparison of experimental and ab initio-calculated chiroptical data. The antimicrobial activity of the bacterial extract and the isolated compounds were assayed using a set of microorganisms, and cytotoxic activities were determined against 36 human cancer cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 1281-1291 |
| Number of pages | 11 |
| Journal | Natural Product Research |
| Volume | 35 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2021 |
Bibliographical note
Funding Information:This work was financed by a grant from the Bundesministerium für Bildung und Forschung (BMBF, grant 03F04153A). We thank R. Machinek for the NMR spectra, Dr. H. Frauendorf for the mass spectra, and F. Lissy and A. Kohl for technical assistance.
Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
- Boshramycinones A-C
- anthracyclinones
- biological activity
- marine Streptomycessp
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Plant Science
- Organic Chemistry
