Bpur, the lyme disease spirochete's PUR domain protein: Identification as a transcriptional modulator and characterization of nucleic acid interactions

Brandon L. Jutras, Alicia M. Chenail, Dustin W. Carroll, M. Clarke Miller, Haining Zhu, Amy Bowman, Brian Stevenson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Borrelia burgdorferi controls protein production during its infectious cycle. Results: Bpur was identified and shown to enhance effects of the erp transcriptional repressor, BpaB. Details of Bpur-nucleic acid interactions were obtained. Conclusion: Bpur participates in regulation of protein expression. Significance:Anew bacterial regulatory factor was identified and insight garnered on mechanisms by which Bpur interacts with nucleic acids.

Original languageEnglish
Pages (from-to)26220-26234
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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