TY - JOUR
T1 - Brain activity during stimulation of the trigeminal nerve with noxious heat
AU - de Leeuw, Reny
AU - Davis, C. Ervin
AU - Albuquerque, Romulo
AU - Carlson, Charles R.
AU - Andersen, Anders H.
PY - 2006/12
Y1 - 2006/12
N2 - Objective: The aim of this study was to observe areas of brain activation with painful hot stimulation to the trigeminal nerve. Study design: Nine healthy pain-free women (mean age 26.2 ± 6.9 yrs) with a natural, regular menstrual cycle participated in the study. Whole-brain functional magnetic resonance imaging (fMRI) data were acquired for each participant on day 2 or 3 after the onset of menses using echo-planar imaging at 1.5T with near-isotropic spatial resolution and a temporal resolution of 4 s. Results: Whole-brain fMRI with a Peltier thermode inside the head coil yielded a feasible imaging protocol with little disturbance from the thermode. Painful thermal stimulation of the left trigeminal system activated discrete brain regions within the insula, cingulate gyrus, thalamus, inferior parietal lobe/postcentral gyrus, right middle and inferior frontal gyri, cuneus, precuneus, and precentral gyrus. Conclusion: Painful stimulation of the trigeminal nerve resulted in activation of similar brain areas generally known for pain processing of painful peripheral stimulation.
AB - Objective: The aim of this study was to observe areas of brain activation with painful hot stimulation to the trigeminal nerve. Study design: Nine healthy pain-free women (mean age 26.2 ± 6.9 yrs) with a natural, regular menstrual cycle participated in the study. Whole-brain functional magnetic resonance imaging (fMRI) data were acquired for each participant on day 2 or 3 after the onset of menses using echo-planar imaging at 1.5T with near-isotropic spatial resolution and a temporal resolution of 4 s. Results: Whole-brain fMRI with a Peltier thermode inside the head coil yielded a feasible imaging protocol with little disturbance from the thermode. Painful thermal stimulation of the left trigeminal system activated discrete brain regions within the insula, cingulate gyrus, thalamus, inferior parietal lobe/postcentral gyrus, right middle and inferior frontal gyri, cuneus, precuneus, and precentral gyrus. Conclusion: Painful stimulation of the trigeminal nerve resulted in activation of similar brain areas generally known for pain processing of painful peripheral stimulation.
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U2 - 10.1016/j.tripleo.2005.12.018
DO - 10.1016/j.tripleo.2005.12.018
M3 - Article
C2 - 17138177
AN - SCOPUS:33751340834
SN - 1079-2104
VL - 102
SP - 750
EP - 757
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 6
ER -