TY - JOUR
T1 - Brain aging correlates
T2 - Retardation by hormonal-pharmacological treatments
AU - Landfield, P. W.
AU - Baskin, R. K.
AU - Pitler, T. A.
PY - 1981
Y1 - 1981
N2 - Mid-aged rats were either adrenalectomized and chronically maintained, or left intact and treated daily for a 9- to 10-month period with a potent analog of the peptide adrenocorticotropin (residues 4 to 9), which has some stimulant properties, or with the neural stimulant pentylenetetrazole. All three treatments reduced hippocampal morphologic correlates of brain aging (neuronal loss, glial reactivity). The pentylenetetrazole and peptide treatments also improved reversal learning. These results suggest that certain endogenous peptides, with stimulant properties, may also exert long-term, trophic effects on brain structure and function.
AB - Mid-aged rats were either adrenalectomized and chronically maintained, or left intact and treated daily for a 9- to 10-month period with a potent analog of the peptide adrenocorticotropin (residues 4 to 9), which has some stimulant properties, or with the neural stimulant pentylenetetrazole. All three treatments reduced hippocampal morphologic correlates of brain aging (neuronal loss, glial reactivity). The pentylenetetrazole and peptide treatments also improved reversal learning. These results suggest that certain endogenous peptides, with stimulant properties, may also exert long-term, trophic effects on brain structure and function.
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U2 - 10.1126/science.6270791
DO - 10.1126/science.6270791
M3 - Article
C2 - 6270791
AN - SCOPUS:0019790481
SN - 0036-8075
VL - 214
SP - 581
EP - 584
JO - Science
JF - Science
IS - 4520
ER -