Brain expression of pCREB in rats exposed to consummatory successive negative contrast

Amanda C. Glueck, Torry S. Dennis, Linda I. Perrotti, Carmen Torres, Mauricio R. Papini

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A 32-to-4% sucrose devaluation leads to suppression of consummatory behavior relative to unshifted 4% sucrose controls. This is accompanied by an emotional response inducing memory consolidation. Expression levels of phosphorylated cyclic adenosine monophosphate response element-binding protein (pCREB, a marker of synaptic plasticity) were higher after the first devaluation session than after the second in prelimbic cortex, anterior cingulate cortex, and dorso-medial striatum. The central nucleus of the amygdala showed a tendency to differential pCREB expression. This evidence contributes to identifying the brain circuit for one form of traumatic memory involving reward loss.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalNeuroscience Letters
StatePublished - Feb 5 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ireland Ltd.


  • Anterior cingulate
  • Consummatory successive negative contrast
  • Dorsal striatum
  • Memory consolidation
  • Prelimbic cortex

ASJC Scopus subject areas

  • Neuroscience (all)


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