Abstract
Dihydropyridine calcium channel blockers may be effective treatment for acute cerebral ischemia, but the uptake of these drugs into the brain is unknown. A 0.2‐ml bolus of [14C]nicardipine hydrochloride and [3H] water was injected into the common carotid arteries of 7 normal and 7 ischemic rats. The corrected first‐pass extraction of nicardipine, compared to water, was calculated to be 30.7% into the hemispheres and 42.3% into the hippocampi. The uptake was greater into the ischemic hemispheres (p ≤ 0.001). These data suggest that dihydropyridines are available to binding sites and calcium channels in neurons.
Original language | English |
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Pages (from-to) | 171-175 |
Number of pages | 5 |
Journal | Annals of Neurology |
Volume | 21 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1987 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology