Brain extraction of a calcium channel blocker

James C. Grotta, L. Creed Pettigrew, Alan H. Lockwood, Catherine Reich

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Dihydropyridine calcium channel blockers may be effective treatment for acute cerebral ischemia, but the uptake of these drugs into the brain is unknown. A 0.2‐ml bolus of [14C]nicardipine hydrochloride and [3H] water was injected into the common carotid arteries of 7 normal and 7 ischemic rats. The corrected first‐pass extraction of nicardipine, compared to water, was calculated to be 30.7% into the hemispheres and 42.3% into the hippocampi. The uptake was greater into the ischemic hemispheres (p ≤ 0.001). These data suggest that dihydropyridines are available to binding sites and calcium channels in neurons.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalAnnals of Neurology
Issue number2
StatePublished - Feb 1987

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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