Brain insulin controls adipose tissue lipolysis and lipogenesis

Thomas Scherer; James OHare; Kelly Diggs-Andrews; Martina Schweiger; Bob Cheng; Claudia Lindtner; Elizabeth Zielinski; Prashant Vempati; Kai Su; Shveta Dighe; Thomas Milsom; Michelle Puchowicz; Ludger Scheja; Rudolf Zechner; Simon J. Fisher; Stephen F. Previs; Christoph Buettner

doi:10.1016/j.cmet.2011.01.008

Brain insulin controls adipose tissue lipolysis and lipogenesis

Thomas Scherer, James OHare, Kelly Diggs-Andrews, Martina Schweiger, Bob Cheng, Claudia Lindtner, Elizabeth Zielinski, Prashant Vempati, Kai Su, Shveta Dighe, Thomas Milsom, Michelle Puchowicz, Ludger Scheja, Rudolf Zechner, Simon J. Fisher, Stephen F. Previs, Christoph Buettner

Research output: Contribution to journal › Article › peer-review

215 Scopus citations

Abstract

White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.

Original language	English
Pages (from-to)	183-194
Number of pages	12
Journal	Cell Metabolism
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2011.01.008
State	Published - Feb 2 2011

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

UN SDGs

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10.1016/j.cmet.2011.01.008

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Scherer, T., OHare, J., Diggs-Andrews, K., Schweiger, M., Cheng, B., Lindtner, C., Zielinski, E., Vempati, P., Su, K., Dighe, S., Milsom, T., Puchowicz, M., Scheja, L., Zechner, R., Fisher, S. J., Previs, S. F., & Buettner, C. (2011). Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metabolism, 13(2), 183-194. https://doi.org/10.1016/j.cmet.2011.01.008

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abstract = "White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.",

author = "Thomas Scherer and James OHare and Kelly Diggs-Andrews and Martina Schweiger and Bob Cheng and Claudia Lindtner and Elizabeth Zielinski and Prashant Vempati and Kai Su and Shveta Dighe and Thomas Milsom and Michelle Puchowicz and Ludger Scheja and Rudolf Zechner and Fisher, {Simon J.} and Previs, {Stephen F.} and Christoph Buettner",

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AU - Lindtner, Claudia

AU - Zielinski, Elizabeth

AU - Vempati, Prashant

AU - Su, Kai

AU - Dighe, Shveta

AU - Milsom, Thomas

AU - Puchowicz, Michelle

AU - Scheja, Ludger

AU - Zechner, Rudolf

AU - Fisher, Simon J.

AU - Previs, Stephen F.

AU - Buettner, Christoph

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AB - White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.

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Brain insulin controls adipose tissue lipolysis and lipogenesis

Abstract

ASJC Scopus subject areas

UN SDGs

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