Neuronal function demands high-level energy production, and as such, a decline in mitochondrial respiration characterizes brain injury and disease. A growing number of studies, however, link brain mitochondrial function to behavioral modulation in non-diseased contexts. In the honey bee, we show for the first time that an acute social interaction, which invokes an aggressive response, may also cause a rapid decline in brain mitochondrial bioenergetics. The degree and speed of this decline has only been previously observed in the context of brain injury. Furthermore, in the honey bee, age-related increases in aggressive tendency are associated with increased baseline brain mitochondrial respiration, as well as increased plasticity in response to metabolic fuel type in vitro. Similarly, diet restriction and ketone body feeding, which commonly enhance mammalian brain mitochondrial function in vivo, cause increased aggression. Thus, even in normal behavioral contexts, brain mitochondria show a surprising degree of variation in function over both rapid and prolonged time scales, with age predicting both baseline function and plasticity in function. These results suggest that mitochondrial function is integral to modulating aggression-related neuronal signaling. We hypothesize that variation in function reflects mitochondrial calcium buffering activity, and that shifts in mitochondrial function signal to the neuronal soma to regulate gene expression and neural energetic state. Modulating brain energetic state is emerging as a critical component of the regulation of behavior in non-diseased contexts.
|Journal||Journal of Experimental Biology|
|State||Published - Apr 2018|
Bibliographical noteFunding Information:
This work was supported in part by the University of Kentucky Office of the Vice President for Research Support Grant (C.C.R.) and a Merit Review Award (I01BX003405 to P.G.S.) from the US Department of Veterans Affairs Biomedical Laboratory Research and Development Program. The contents of this paper do not represent the views of the US Department of Veterans Affairs or the United States Government.
© 2018. Published by The Company of Biologists Ltd | Journal of Experimental Biology.
- Alzheimer's disease
- Behavioral plasticity
- Neural energetics
- Traumatic brain injury
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Aquatic Science
- Animal Science and Zoology
- Molecular Biology
- Insect Science