Brain Neuron Preparations for the Study of Aging Changes in Calcium Potentials and Currents

Olivier Thibault; Mary L. Mazzanti; Eric M. Blalock; Nada M. Porter; Philip W. Landfield

doi:10.1006/ncmn.1994.1023

Brain Neuron Preparations for the Study of Aging Changes in Calcium Potentials and Currents

Olivier Thibault, Mary L. Mazzanti, Eric M. Blalock, Nada M. Porter, Philip W. Landfield

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This article considers the problems encountered in the study of basic electrophysiologlcal properties of aged animal brain cells and describes several methods that are useful for such studies. Specific methods for rat brain slice preparations are reviewed, with an emphasis on factors relevant to aging animals. Alternative approaches (acutely dissociated cells) are also considered. Methods for investigating pharmacologically isolated and defined calcium potentials and calcium currents in aged rat brain neurons also are described. These may play an important role in the brain aging process.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Neuroprotocols
Volume	4
Issue number	3
DOIs	https://doi.org/10.1006/ncmn.1994.1023
State	Published - Jun 1994

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abstract = "This article considers the problems encountered in the study of basic electrophysiologlcal properties of aged animal brain cells and describes several methods that are useful for such studies. Specific methods for rat brain slice preparations are reviewed, with an emphasis on factors relevant to aging animals. Alternative approaches (acutely dissociated cells) are also considered. Methods for investigating pharmacologically isolated and defined calcium potentials and calcium currents in aged rat brain neurons also are described. These may play an important role in the brain aging process.",

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AU - Landfield, Philip W.

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AB - This article considers the problems encountered in the study of basic electrophysiologlcal properties of aged animal brain cells and describes several methods that are useful for such studies. Specific methods for rat brain slice preparations are reviewed, with an emphasis on factors relevant to aging animals. Alternative approaches (acutely dissociated cells) are also considered. Methods for investigating pharmacologically isolated and defined calcium potentials and calcium currents in aged rat brain neurons also are described. These may play an important role in the brain aging process.

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Brain Neuron Preparations for the Study of Aging Changes in Calcium Potentials and Currents

Abstract

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