TY - JOUR
T1 - Brain oxidative stress in animal models of accelerated aging and the age related neurodegenerative disorders, Alzheimer's disease and Huntington's disease
AU - Allan Butterfield, D.
AU - Howard, Beverly J.
AU - Lafontaine, Michael A.
PY - 2001
Y1 - 2001
N2 - Oxidative stress in brain is emerging as a potential causal factor in aging and age-related neurodegenerative disorders. Brain tissue from living patients is difficult to acquire; hence, animal models of aging and age-related neurodegenerative disorders, though not perfect models, have provided tissue to study the role of oxidative stress in these disorders. In this review, the central role of oxidative damage in brain in models of accelerated aging (progeria and Werner's syndrome) and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease, will be presented and evaluated. To the extent that the animal models faithfully mirror their respective disorders, and based on the totality of the studies, it is apparent that oxidative stress, the excess of free radicals over the means of scavenging these harmful agents, may play critical roles in the molecular basis of accelerated aging, Alzheimer's disease, and Huntington's disease.
AB - Oxidative stress in brain is emerging as a potential causal factor in aging and age-related neurodegenerative disorders. Brain tissue from living patients is difficult to acquire; hence, animal models of aging and age-related neurodegenerative disorders, though not perfect models, have provided tissue to study the role of oxidative stress in these disorders. In this review, the central role of oxidative damage in brain in models of accelerated aging (progeria and Werner's syndrome) and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease, will be presented and evaluated. To the extent that the animal models faithfully mirror their respective disorders, and based on the totality of the studies, it is apparent that oxidative stress, the excess of free radicals over the means of scavenging these harmful agents, may play critical roles in the molecular basis of accelerated aging, Alzheimer's disease, and Huntington's disease.
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U2 - 10.2174/0929867013373048
DO - 10.2174/0929867013373048
M3 - Article
C2 - 11375752
AN - SCOPUS:0035013564
SN - 0929-8673
VL - 8
SP - 815
EP - 828
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 7
ER -