BRCA1 16 years later: DNA damage-induced BRCA1 shuttling

Eddy S. Yang, Fen Xia

Research output: Contribution to journalShort surveypeer-review

36 Scopus citations

Abstract

The tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end-joining-mediated DNA repair following DNA damage will be reviewed, as well as the activation of apoptotic pathways. The control of these functions via DNA damage-induced BRCA1 shuttling will also be discussed, in particular BRCA1 shuttling induced by erlotinib and irradiation. Finally, the potential targeting of BRCA1 shuttling as a novel strategy to sensitize cells to DNA damage will be entertained.

Original languageEnglish
Pages (from-to)3079-3085
Number of pages7
JournalFEBS Journal
Volume277
Issue number15
DOIs
StatePublished - Aug 2010

Keywords

  • BRCA1
  • DNA damage
  • DNA repair
  • homologous recombination
  • nonhomologous end-joining

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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