Abstract
The tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end-joining-mediated DNA repair following DNA damage will be reviewed, as well as the activation of apoptotic pathways. The control of these functions via DNA damage-induced BRCA1 shuttling will also be discussed, in particular BRCA1 shuttling induced by erlotinib and irradiation. Finally, the potential targeting of BRCA1 shuttling as a novel strategy to sensitize cells to DNA damage will be entertained.
| Original language | English |
|---|---|
| Pages (from-to) | 3079-3085 |
| Number of pages | 7 |
| Journal | FEBS Journal |
| Volume | 277 |
| Issue number | 15 |
| DOIs | |
| State | Published - Aug 2010 |
Funding
| Funders | Funder number |
|---|---|
| National Childhood Cancer Registry – National Cancer Institute | R01CA118158 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- BRCA1
- DNA damage
- DNA repair
- homologous recombination
- nonhomologous end-joining
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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