TY - JOUR
T1 - Breast and thyroid cancer
T2 - A multicenter study with Accrual to Clinical Trials Network
AU - Peckham, Merry
AU - Spencer, Horace J.
AU - Syed, Shorabuddin
AU - Armstrong, William B.
AU - Farwell, Donald Gregory
AU - Gal, Thomas J.
AU - Goldenberg, David
AU - Russell, Marika D.
AU - Solis, Roberto N.
AU - King, Deanne
AU - Stack, Brendan C.
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/6/15
Y1 - 2022/6/15
N2 - Objective: To investigate a possible link between breast and thyroid cancer. Methods: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. Results: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50–5.18). Conclusion: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.
AB - Objective: To investigate a possible link between breast and thyroid cancer. Methods: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. Results: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50–5.18). Conclusion: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.
KW - breast cancer
KW - epidemiology
KW - thyroid cancer
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U2 - 10.1002/jso.26825
DO - 10.1002/jso.26825
M3 - Article
C2 - 35195923
AN - SCOPUS:85125051591
SN - 0022-4790
VL - 125
SP - 1211
EP - 1217
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 8
ER -
