Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase

Tanya Meyer, Li Hui Xu, Jinli Chang, Edison T. Lui, Rolf J. Craven, William G. Cance

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Rak is a 54 kDa protein tyrosine kinase originally isolated from breast cancer cells and expressed in epithelial cells. It resembles the protooncogene Src structurally but lacks an amino-terminal myristylation site and localizes to the nuclear and perinuclear regions of the cell. We report here that expression of Rak in 2 different breast cancer cell lines inhibits growth and causes G1 arrest of the cell cycle. This growth inhibition is kinase-dependent but does not require the Rak SH2 or SH3 domain. Rak also binds to the pRb tumor-suppressor protein but inhibits growth even in cells that lack pRb. These results suggest that Rak regulates cell growth by phosphorylating perinuclear proteins and has a function that is distinct from the Src-related kinase family.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalInternational Journal of Cancer
Issue number2
StatePublished - Mar 20 2003


  • Breast cancer
  • Cell cycle
  • Rak
  • Src
  • Tyrosine kinase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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