Breast Implant-associated Anaplastic Large Cell Lymphoma: An Evidence-based Systematic Review

Ryan C. DeCoster, Evan B. Lynch, Alisha R. Bonaroti, John Matthew Webster, Timothy A. Butterfield, Bernard Mark Evers, Henry C. Vasconez, Mark W. Clemens

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective:This evidence-based systematic review synthesizes and critically appraises current clinical recommendations and advances in the diagnosis and treatment of BIA-ALCL. This review also aims to broaden physician awareness across diverse specialties, particularly among general practitioners, breast surgeons, surgical oncologists, and other clinicians who may encounter patients with breast implants in their practice.Background:BIA-ALCL is an emerging and treatable immune cell cancer definitively linked to textured-surface breast implants. Although the National Comprehensive Cancer Network (NCCN) consensus guidelines and other clinical recommendations have been established, the evidence supporting these guidelines has not been systematically studied. The purpose of this evidence-based systematic review is to synthesize and critically appraise current clinical guidelines and recommendations while highlighting advances in diagnosis and treatment and raising awareness for this emerging disease.Methods:This evidence-based systematic review evaluated primary research studies focusing on the diagnosis and treatment of BIA-ALCL that were published in PubMed, Google Scholar, and other scientific databases through March 2020.Results and Conclusions:The clinical knowledge of BIA-ALCL has evolved rapidly over the last several years with major advances in diagnosis and treatment, including en bloc resection as the standard of care. Despite a limited number of high-quality clinical studies comprised mainly of Level III and Level V evidence, current evidence aligns with established NCCN consensus guidelines. When diagnosed and treated in accordance with NCCN guidelines, BIA-ALCL carries an excellent prognosis.

Original languageEnglish
Pages (from-to)449-458
Number of pages10
JournalAnnals of Surgery
Issue number3
StatePublished - Mar 1 2021

Bibliographical note

Funding Information:
RCD is supported by a National Cancer Institute Surgeon-Scientist training grant (T32CA160003).

Publisher Copyright:
© 2020 Wolters Kluwer Health, Inc. All rights reserved.


  • breast implants
  • lymphoma
  • systematic review

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Breast Implant-associated Anaplastic Large Cell Lymphoma: An Evidence-based Systematic Review'. Together they form a unique fingerprint.

Cite this