Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis

Mehdi Khosravi; Paul B. Collins; Ruei Lung Lin; Don Hayes; Jaclyn A. Smith; Lu Yuan Lee

doi:10.1016/j.resp.2014.03.013

Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis

Mehdi Khosravi
, Paul B. Collins
, Ruei Lung Lin
, Don Hayes
, Jaclyn A. Smith
, Lu Yuan Lee

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4. min of humidified hot air (HA; 49. °C) and room air (RA; 21. °C) were compared between AR patients (n= 7) and healthy subjects (n= 6). In AR patients, cough frequency increased pronouncedly from 0.10 ± 0.07 before to 2.37 ± 0.73 during, and 1.80 ± 0.79. coughs/min for the first 8. min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways.

Original language	English
Pages (from-to)	13-19
Number of pages	7
Journal	Respiratory Physiology and Neurobiology
Volume	198
Issue number	1
DOIs	https://doi.org/10.1016/j.resp.2014.03.013
State	Published - Jul 1 2014

Bibliographical note

Funding Information:
This study was supported in part by the NIH grants HL-67379 and HL-96914 (to L.Y.L.), Department of Defense DMRDP/ARATD award administered by the U.S. Army Medical Research & Materiel Command (USAMRMC) Telemedicine & Advanced Technology Research Center (TATRC) under Contract Number W81XWH-10-2-0189 (to L.Y.L.), University of Kentucky Clinical Research Development & Operations Center grant UL1TR000117 and Kentucky Pediatric Research Institute support (to D.H.).

Funding

This study was supported in part by the NIH grants HL-67379 and HL-96914 (to L.Y.L.), Department of Defense DMRDP/ARATD award administered by the U.S. Army Medical Research & Materiel Command (USAMRMC) Telemedicine & Advanced Technology Research Center (TATRC) under Contract Number W81XWH-10-2-0189 (to L.Y.L.), University of Kentucky Clinical Research Development & Operations Center grant UL1TR000117 and Kentucky Pediatric Research Institute support (to D.H.).

Funders	Funder number
ARATD
Department of Defense DMRDP
Kentucky Pediatric Research Institute
University of Kentucky Clinical Research Development and Operations Center
National Institutes of Health (NIH)	R55HL067379, R01HL096914
Army Medical Research and Materiel Command
National Center for Advancing Translational Sciences (NCATS)	UL1TR000117
Telemedicine and Advanced Technology Research Center	W81XWH-10-2-0189

Keywords

Airway irritation
Allergic rhinitis
Cough
Laryngeal
TRPV1

ASJC Scopus subject areas

General Neuroscience
Physiology
Pulmonary and Respiratory Medicine

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10.1016/j.resp.2014.03.013

Cite this

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title = "Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis",

abstract = "We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40\% of maximal voluntary ventilation) for 4. min of humidified hot air (HA; 49. °C) and room air (RA; 21. °C) were compared between AR patients (n= 7) and healthy subjects (n= 6). In AR patients, cough frequency increased pronouncedly from 0.10 ± 0.07 before to 2.37 ± 0.73 during, and 1.80 ± 0.79. coughs/min for the first 8. min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways.",

keywords = "Airway irritation, Allergic rhinitis, Cough, Laryngeal, TRPV1",

author = "Mehdi Khosravi and Collins, \{Paul B.\} and Lin, \{Ruei Lung\} and Don Hayes and Smith, \{Jaclyn A.\} and Lee, \{Lu Yuan\}",

note = "Funding Information: This study was supported in part by the NIH grants HL-67379 and HL-96914 (to L.Y.L.), Department of Defense DMRDP/ARATD award administered by the U.S. Army Medical Research \& Materiel Command (USAMRMC) Telemedicine \& Advanced Technology Research Center (TATRC) under Contract Number W81XWH-10-2-0189 (to L.Y.L.), University of Kentucky Clinical Research Development \& Operations Center grant UL1TR000117 and Kentucky Pediatric Research Institute support (to D.H.). ",

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AU - Smith, Jaclyn A.

AU - Lee, Lu Yuan

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N2 - We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4. min of humidified hot air (HA; 49. °C) and room air (RA; 21. °C) were compared between AR patients (n= 7) and healthy subjects (n= 6). In AR patients, cough frequency increased pronouncedly from 0.10 ± 0.07 before to 2.37 ± 0.73 during, and 1.80 ± 0.79. coughs/min for the first 8. min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways.

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Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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