Abstract
Fluorinated aryl- and heteroaryl-substituted monohydrazones displayed excellent broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis of murine red blood cells than that of VRC at the same concentrations, possessed fungicidal activity in a time-kill study, and exhibited no mammalian cell cytotoxicity. In addition, these monohydrazones prevented the formation of biofilms that otherwise block antibiotic effectiveness and did not trigger the development of resistance when exposed to C. auris AR Bank # 0390 over 15 passages.
Original language | English |
---|---|
Pages (from-to) | 124-133 |
Number of pages | 10 |
Journal | ChemMedChem |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Jan 8 2021 |
Bibliographical note
Publisher Copyright:© 2020 Wiley-VCH GmbH
Keywords
- Biofilm
- Candida auris
- Cytotoxicity
- Drug resistance
- Hemolysis
- Monohydrazones
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Drug Discovery
- General Pharmacology, Toxicology and Pharmaceutics
- Organic Chemistry