TY - GEN
T1 - Brush-on fabrication of suspended PLLA-PEO-PLLA triblock copolymer fibers
AU - Berry, Scott M.
AU - Pabba, Santosh
AU - Fernandes, Jessica L.
AU - Rathfon, Jeremy M.
AU - Aamer, Khaled A.
AU - Tew, Gregory N.
AU - Gobin, Andrea S.
AU - Cohn, Robert W.
AU - Keynton, Robert S.
PY - 2007
Y1 - 2007
N2 - Parallel fibers can be rapidly created by manually brushing solvated polymer solutions over arrays of micro-fabricated pillars. Recently, this technique has been utilized to produce suspended arrays of micron and sub-micron scale fibers consisting of a new triblock copolymer composed of a hydrophilic mid-block of polyethylene oxide (PEO) surrounded by two hydrophobic end groups of poly-L-lactic acid (PLLA). A solution of this polymer in chloroform has been used to fabricate fibers with diameters ranging from 125 nm to >50 μm. Annealing these fibers in water induces the formation of ultrastructural nanoscale pores that can be selectively oriented through variation of the surface treatment. Because the PLLA-PEO-PLLA triblock copolymer is both biocompatible and biodegradable, these arrays of fibers are excellent candidates for biomimetic extracellular matrix (ECM) structures. Additionally, the porous ultrastructure of the fibers may provide a platform for the in situ delivery of growth factors to stimulate endothelial cell proliferation, migration, and lumen formation.
AB - Parallel fibers can be rapidly created by manually brushing solvated polymer solutions over arrays of micro-fabricated pillars. Recently, this technique has been utilized to produce suspended arrays of micron and sub-micron scale fibers consisting of a new triblock copolymer composed of a hydrophilic mid-block of polyethylene oxide (PEO) surrounded by two hydrophobic end groups of poly-L-lactic acid (PLLA). A solution of this polymer in chloroform has been used to fabricate fibers with diameters ranging from 125 nm to >50 μm. Annealing these fibers in water induces the formation of ultrastructural nanoscale pores that can be selectively oriented through variation of the surface treatment. Because the PLLA-PEO-PLLA triblock copolymer is both biocompatible and biodegradable, these arrays of fibers are excellent candidates for biomimetic extracellular matrix (ECM) structures. Additionally, the porous ultrastructure of the fibers may provide a platform for the in situ delivery of growth factors to stimulate endothelial cell proliferation, migration, and lumen formation.
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M3 - Conference contribution
AN - SCOPUS:36049025552
SN - 1604232226
SN - 9781604232226
T3 - Proceedings of the SEM Annual Conference and Exposition on Experimental and Applied Mechanics 2007
SP - 515
EP - 521
BT - Proceedings of the SEM Annual Conference and Exposition on Experimental and Applied Mechanics 2007
T2 - SEM Annual Conference and Exposition on Experimental and Applied Mechanics 2007
Y2 - 3 June 2007 through 6 June 2007
ER -