During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.
|Number of pages||5|
|State||Published - Jan 3 1994|
Bibliographical noteFunding Information:
Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.
- Circadian rhythm
- Hypothalamus, Circannual rhythm
- Transcriptional regulation
ASJC Scopus subject areas
- Neuroscience (all)