C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

Louise Bitting; Ellen L. Sutin; Fiona L. Watson; Lorriana E. Leard; Bruce F. O'Hara; H. Craig Heller; Thomas S. Kilduff

doi:10.1016/0304-3940(94)90723-4

C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

Louise Bitting, Ellen L. Sutin, Fiona L. Watson, Lorriana E. Leard, Bruce F. O'Hara, H. Craig Heller, Thomas S. Kilduff

Biology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.

Original language	English
Pages (from-to)	117-121
Number of pages	5
Journal	Neuroscience Letters
Volume	165
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90723-4
State	Published - Jan 3 1994

Bibliographical note

Funding Information:
Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.

Keywords

Arousal
Circadian rhythm
Fos
Hypothalamus, Circannual rhythm
Transcriptional regulation

ASJC Scopus subject areas

Neuroscience (all)

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10.1016/0304-3940(94)90723-4

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title = "C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation",

abstract = "During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.",

keywords = "Arousal, Circadian rhythm, Fos, Hypothalamus, Circannual rhythm, Transcriptional regulation",

author = "Louise Bitting and Sutin, {Ellen L.} and Watson, {Fiona L.} and Leard, {Lorriana E.} and O'Hara, {Bruce F.} and {Craig Heller}, H. and Kilduff, {Thomas S.}",

note = "Funding Information: Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.",

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doi = "10.1016/0304-3940(94)90723-4",

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AU - Bitting, Louise

AU - Sutin, Ellen L.

AU - Watson, Fiona L.

AU - Leard, Lorriana E.

AU - O'Hara, Bruce F.

AU - Craig Heller, H.

AU - Kilduff, Thomas S.

N1 - Funding Information: Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.

PY - 1994/1/3

Y1 - 1994/1/3

N2 - During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.

AB - During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.

KW - Arousal

KW - Circadian rhythm

KW - Fos

KW - Hypothalamus, Circannual rhythm

KW - Transcriptional regulation

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C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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