Ca 2+ regulation and gene expression in normal brain aging

Emil C. Toescu, Alexei Verkhratsky, Philip W. Landfield

Research output: Contribution to journalReview articlepeer-review

186 Scopus citations

Abstract

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca 2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca 2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

Original languageEnglish
Pages (from-to)614-620
Number of pages7
JournalTrends in Neurosciences
Volume27
Issue number10
DOIs
StatePublished - Oct 2004

Bibliographical note

Funding Information:
E.C.T. and A.V. thank the BBSRC, which funded, through the Science of Ageing Initiative, part of the work described in this review. Aspects of the research were also supported by grants AG04542 and AG10836 from the NIA to P.L.

ASJC Scopus subject areas

  • Neuroscience (all)

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