Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca 2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca 2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
|Number of pages||7|
|Journal||Trends in Neurosciences|
|State||Published - Oct 2004|
Bibliographical noteFunding Information:
E.C.T. and A.V. thank the BBSRC, which funded, through the Science of Ageing Initiative, part of the work described in this review. Aspects of the research were also supported by grants AG04542 and AG10836 from the NIA to P.L.
ASJC Scopus subject areas
- Neuroscience (all)