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82 Scopus citations


The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates. These substrates include, but are not limited to, transcription factors, receptors and channels, proteins associated with mitochondria, and proteins associated with microtubules. Calcineurin is activated by increases in intracellular calcium concentrations, a process that requires the calcium sensing protein calmodulin binding to an intrinsically disordered regulatory domain in the phosphatase. Despite having been studied for around four decades, the activation of calcineurin is not fully understood. This review largely focuses on what is known about the activation process and highlights aspects that are currently not understood. [MediaObject not available: see fulltext.].

Original languageEnglish
Article number137
JournalCell Communication and Signaling
Issue number1
StatePublished - Aug 28 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s).


  • Calcineurin
  • Calcium
  • Calmodulin
  • Channels
  • Intrinsically-disordered region
  • Microtubules
  • Mitochondria
  • Receptors
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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