TY - JOUR
T1 - Calcitonin, somatostatin and ACTH immunoreactive cells in a case of familial bilateral thyroid medullary carcinoma
AU - Charpin, Colette
AU - Andrac, Lucile
AU - Monier‐Faugere, Marie Claude
AU - Hassoun, Jacques
AU - Cannoni, Maurice
AU - Vagneur, Jean Paul
AU - Toga, Maurice
PY - 1982/11/1
Y1 - 1982/11/1
N2 - Bilateral medullary carcinoma of the thyroid (MCT) was discovered in a symptomless patient of a high‐risk MCT family. Raised serum calcitonin responding abnormally to pentagastrin led to a thyroidectomy. Grossly, the thyroid showed one nodule in the upper third of each lobe. Light microscopy revealed typical MCT with amyloid deposits. Nontumoral thyroid tissue showed C cell parafollicular hyperplasia. Electron microscopy detected intracellular secretory granules (mean diameter, 150 nm) and typical amyloid fibrills. Immunochemistry revealed numerous calcitonin immunoreactive cells in the nodules, in normal para and intrafollicular C‐cells and hyperplasic C‐cells. Somatostatin and ACTH were detected in certain tumor cells, but not in normal and hyperplasic C‐cells. MCT hormonal production potential is discussed. Cancer 50:1806‐1184, 1982.
AB - Bilateral medullary carcinoma of the thyroid (MCT) was discovered in a symptomless patient of a high‐risk MCT family. Raised serum calcitonin responding abnormally to pentagastrin led to a thyroidectomy. Grossly, the thyroid showed one nodule in the upper third of each lobe. Light microscopy revealed typical MCT with amyloid deposits. Nontumoral thyroid tissue showed C cell parafollicular hyperplasia. Electron microscopy detected intracellular secretory granules (mean diameter, 150 nm) and typical amyloid fibrills. Immunochemistry revealed numerous calcitonin immunoreactive cells in the nodules, in normal para and intrafollicular C‐cells and hyperplasic C‐cells. Somatostatin and ACTH were detected in certain tumor cells, but not in normal and hyperplasic C‐cells. MCT hormonal production potential is discussed. Cancer 50:1806‐1184, 1982.
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U2 - 10.1002/1097-0142(19821101)50:9<1806::AID-CNCR2820500926>3.0.CO;2-I
DO - 10.1002/1097-0142(19821101)50:9<1806::AID-CNCR2820500926>3.0.CO;2-I
M3 - Article
C2 - 6126268
AN - SCOPUS:0019904211
SN - 0008-543X
VL - 50
SP - 1806
EP - 1814
JO - Cancer
JF - Cancer
IS - 9
ER -
