TY - JOUR
T1 - Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
AU - Maswood, Navin
AU - Young, Jennifer
AU - Tilmont, Edward
AU - Zhang, Zhiming
AU - Gash, Don M.
AU - Gerhardt, Greg A.
AU - Grondin, Richard
AU - Roth, George S.
AU - Mattison, Julie
AU - Lane, Mark A.
AU - Carson, Richard E.
AU - Cohen, Robert M.
AU - Mouton, Peter R.
AU - Quigley, Christopher
AU - Mattson, Mark P.
AU - Ingram, Donald K.
PY - 2004/12/28
Y1 - 2004/12/28
N2 - We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6 months on a reduced-calorie diet [30% caloric restriction (CR)] or an ad libitum control diet after which they were subjected to treatment with a neurotoxin to produce a hemiparkinson condition. After neurotoxin treatment, CR monkeys exhibited significantly higher levels of locomotor activity compared with control monkeys as well as higher levels of dopamine (DA) and DA metabolites in the striatal region. Increased survival of DA neurons in the substantia nigra and improved manual dexterity were noted but did not reach statistical significance. Levels of glial cell line-derived neurotrophic factor, which is known to promote the survival of DA neurons, were increased significantly in the caudate nucleus of CR monkeys, suggesting a role for glial cell line-derived neurotrophic factor in the anti-Parkinson's disease effect of the low-calorie diet.
AB - We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6 months on a reduced-calorie diet [30% caloric restriction (CR)] or an ad libitum control diet after which they were subjected to treatment with a neurotoxin to produce a hemiparkinson condition. After neurotoxin treatment, CR monkeys exhibited significantly higher levels of locomotor activity compared with control monkeys as well as higher levels of dopamine (DA) and DA metabolites in the striatal region. Increased survival of DA neurons in the substantia nigra and improved manual dexterity were noted but did not reach statistical significance. Levels of glial cell line-derived neurotrophic factor, which is known to promote the survival of DA neurons, were increased significantly in the caudate nucleus of CR monkeys, suggesting a role for glial cell line-derived neurotrophic factor in the anti-Parkinson's disease effect of the low-calorie diet.
KW - Brain-derived neurotrophic factor
KW - Cell death
KW - Dopamine
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UR - http://www.scopus.com/inward/citedby.url?scp=19944427435&partnerID=8YFLogxK
U2 - 10.1073/pnas.0405831102
DO - 10.1073/pnas.0405831102
M3 - Article
C2 - 15604149
AN - SCOPUS:19944427435
SN - 0027-8424
VL - 101
SP - 18171
EP - 18176
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 52
ER -