TY - JOUR
T1 - Cancer prevention with promising natural products
T2 - Mechanisms of action and molecular targets
AU - Pratheeshkumar, Poyil
AU - Sreekala, Chakkenchath
AU - Zhang, Zhuo
AU - Budhraja, Amit
AU - Ding, Songze
AU - Son, Young Ok
AU - Wang, Xin
AU - Hitron, Andrew
AU - Hyun-Jung, Kim
AU - Wang, Lei
AU - Lee, Jeong Chae
AU - Shi, Xianglin
PY - 2012
Y1 - 2012
N2 - Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.
AB - Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.
KW - (-)-epigallocatechin-3-gallate
KW - Activator protein-1
KW - Angiogenesis
KW - Apoptosis
KW - Cell cycle arrest
KW - Chemoprevention
KW - Curcumin
KW - Cyclooxygenase (COX)-2
KW - Isothyocynates
KW - Nuclear factor (NF)-κB
KW - Oxidative stress
KW - Phytochemicals
KW - Resveratrol
UR - http://www.scopus.com/inward/record.url?scp=84870166894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870166894&partnerID=8YFLogxK
U2 - 10.2174/187152012803833035
DO - 10.2174/187152012803833035
M3 - Article
C2 - 22583402
AN - SCOPUS:84870166894
SN - 1871-5206
VL - 12
SP - 1159
EP - 1184
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
IS - 10
ER -
