Cancer-selective apoptosis by tumor suppressor Par-4

Nikhil Hebbar; Tripti Shrestha-Bhattarai; Vivek M. Rangnekar

doi:10.1007/978-1-4471-6458-6_7

Cancer-selective apoptosis by tumor suppressor Par-4

Nikhil Hebbar, Tripti Shrestha-Bhattarai, Vivek M. Rangnekar

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

15 Scopus citations

Abstract

Tumor suppressor genes play an important role in preventing neoplastic transformation and maintaining normal tissue homeostasis. Par-4 is one such tumor suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition of pro-survival pathways and activation of Fas mediated apoptosis whereas extracellular (secreted Par-4) acts by binding to cell surface GRP78 leading to activation of the extrinsic apoptotic pathway. Many studies have highlighted the importance of Par-4 not only in preventing cancer development/recurrence but also as a promising anticancer therapeutic agent.

Original language	English
Title of host publication	Anticancer Genes
Pages	155-166
Number of pages	12
DOIs	https://doi.org/10.1007/978-1-4471-6458-6_7
State	Published - 2014

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	818
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Bibliographical note

Funding Information:
This study was supported by KLCR grant and NIH/NCI grant CA060872 (to VMR). The authors thank the past and present members of the Rangnekar Laboratory and collaborators who contributed to the work described in this review article.

Funding

This study was supported by KLCR grant and NIH/NCI grant CA060872 (to VMR). The authors thank the past and present members of the Rangnekar Laboratory and collaborators who contributed to the work described in this review article.

Funders	Funder number
KLCR
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute	R01CA060872

Keywords

Apoptosis
Extracellular systemic effects
Par-4/PAWR
Prostate cancer
Tumor suppressor protein

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4471-6458-6_7

Cite this

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title = "Cancer-selective apoptosis by tumor suppressor Par-4",

abstract = "Tumor suppressor genes play an important role in preventing neoplastic transformation and maintaining normal tissue homeostasis. Par-4 is one such tumor suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition of pro-survival pathways and activation of Fas mediated apoptosis whereas extracellular (secreted Par-4) acts by binding to cell surface GRP78 leading to activation of the extrinsic apoptotic pathway. Many studies have highlighted the importance of Par-4 not only in preventing cancer development/recurrence but also as a promising anticancer therapeutic agent.",

keywords = "Apoptosis, Extracellular systemic effects, Par-4/PAWR, Prostate cancer, Tumor suppressor protein",

author = "Nikhil Hebbar and Tripti Shrestha-Bhattarai and Rangnekar, \{Vivek M.\}",

note = "Funding Information: This study was supported by KLCR grant and NIH/NCI grant CA060872 (to VMR). The authors thank the past and present members of the Rangnekar Laboratory and collaborators who contributed to the work described in this review article.",

year = "2014",

doi = "10.1007/978-1-4471-6458-6\_7",

language = "English",

isbn = "9781447164579",

series = "Advances in Experimental Medicine and Biology",

pages = "155--166",

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AU - Hebbar, Nikhil

AU - Shrestha-Bhattarai, Tripti

AU - Rangnekar, Vivek M.

N1 - Funding Information: This study was supported by KLCR grant and NIH/NCI grant CA060872 (to VMR). The authors thank the past and present members of the Rangnekar Laboratory and collaborators who contributed to the work described in this review article.

PY - 2014

Y1 - 2014

N2 - Tumor suppressor genes play an important role in preventing neoplastic transformation and maintaining normal tissue homeostasis. Par-4 is one such tumor suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition of pro-survival pathways and activation of Fas mediated apoptosis whereas extracellular (secreted Par-4) acts by binding to cell surface GRP78 leading to activation of the extrinsic apoptotic pathway. Many studies have highlighted the importance of Par-4 not only in preventing cancer development/recurrence but also as a promising anticancer therapeutic agent.

AB - Tumor suppressor genes play an important role in preventing neoplastic transformation and maintaining normal tissue homeostasis. Par-4 is one such tumor suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition of pro-survival pathways and activation of Fas mediated apoptosis whereas extracellular (secreted Par-4) acts by binding to cell surface GRP78 leading to activation of the extrinsic apoptotic pathway. Many studies have highlighted the importance of Par-4 not only in preventing cancer development/recurrence but also as a promising anticancer therapeutic agent.

KW - Apoptosis

KW - Extracellular systemic effects

KW - Par-4/PAWR

KW - Prostate cancer

KW - Tumor suppressor protein

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DO - 10.1007/978-1-4471-6458-6_7

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SN - 9781447164579

T3 - Advances in Experimental Medicine and Biology

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BT - Anticancer Genes

ER -

Cancer-selective apoptosis by tumor suppressor Par-4

Abstract

Publication series

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this