Cancer-selective apoptosis by tumor suppressor Par-4

Nikhil Hebbar, Tripti Shrestha-Bhattarai, Vivek M. Rangnekar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

15 Scopus citations

Abstract

Tumor suppressor genes play an important role in preventing neoplastic transformation and maintaining normal tissue homeostasis. Par-4 is one such tumor suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition of pro-survival pathways and activation of Fas mediated apoptosis whereas extracellular (secreted Par-4) acts by binding to cell surface GRP78 leading to activation of the extrinsic apoptotic pathway. Many studies have highlighted the importance of Par-4 not only in preventing cancer development/recurrence but also as a promising anticancer therapeutic agent.

Original languageEnglish
Title of host publicationAnticancer Genes
Pages155-166
Number of pages12
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume818
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Funding Information:
This study was supported by KLCR grant and NIH/NCI grant CA060872 (to VMR). The authors thank the past and present members of the Rangnekar Laboratory and collaborators who contributed to the work described in this review article.

Funding

This study was supported by KLCR grant and NIH/NCI grant CA060872 (to VMR). The authors thank the past and present members of the Rangnekar Laboratory and collaborators who contributed to the work described in this review article.

FundersFunder number
KLCR
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer InstituteR01CA060872

    Keywords

    • Apoptosis
    • Extracellular systemic effects
    • Par-4/PAWR
    • Prostate cancer
    • Tumor suppressor protein

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology

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