Cancer-selective apoptosis by tumor suppressor Par-4

Nikhil Hebbar, Tripti Shrestha-Bhattarai, Vivek M. Rangnekar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

12 Scopus citations

Abstract

Tumor suppressor genes play an important role in preventing neoplastic transformation and maintaining normal tissue homeostasis. Par-4 is one such tumor suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected. The cancer cell specific activity of Par-4 is elicited through intracellular as well as extracellular mechanisms. Intracellularly Par-4 acts through the inhibition of pro-survival pathways and activation of Fas mediated apoptosis whereas extracellular (secreted Par-4) acts by binding to cell surface GRP78 leading to activation of the extrinsic apoptotic pathway. Many studies have highlighted the importance of Par-4 not only in preventing cancer development/recurrence but also as a promising anticancer therapeutic agent.

Original languageEnglish
Title of host publicationAnticancer Genes
Pages155-166
Number of pages12
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume818
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Funding Information:
This study was supported by KLCR grant and NIH/NCI grant CA060872 (to VMR). The authors thank the past and present members of the Rangnekar Laboratory and collaborators who contributed to the work described in this review article.

Keywords

  • Apoptosis
  • Extracellular systemic effects
  • Par-4/PAWR
  • Prostate cancer
  • Tumor suppressor protein

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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