Abstract
Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.
Original language | English |
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Pages (from-to) | 3873-3880 |
Number of pages | 8 |
Journal | Oncogene |
Volume | 29 |
Issue number | 27 |
DOIs | |
State | Published - Jul 8 2010 |
Bibliographical note
Funding Information:This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).
Keywords
- Par-4
- apoptosis
- cell surface GRP78
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research