Cancer-selective apoptotic effects of extracellular and intracellular Par-4

T. Shrestha-Bhattarai; V. M. Rangnekar

doi:10.1038/onc.2010.141

Cancer-selective apoptotic effects of extracellular and intracellular Par-4

T. Shrestha-Bhattarai, V. M. Rangnekar

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

Original language	English
Pages (from-to)	3873-3880
Number of pages	8
Journal	Oncogene
Volume	29
Issue number	27
DOIs	https://doi.org/10.1038/onc.2010.141
State	Published - Jul 8 2010

Bibliographical note

Funding Information:
This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).

Keywords

Par-4
apoptosis
cell surface GRP78

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/onc.2010.141

Cite this

@article{7fc731af01da464bb247d4522590ca05,

title = "Cancer-selective apoptotic effects of extracellular and intracellular Par-4",

abstract = "Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.",

keywords = "Par-4, apoptosis, cell surface GRP78",

author = "T. Shrestha-Bhattarai and Rangnekar, {V. M.}",

note = "Funding Information: This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).",

year = "2010",

month = jul,

day = "8",

doi = "10.1038/onc.2010.141",

language = "English",

volume = "29",

pages = "3873--3880",

number = "27",

}

TY - JOUR

T1 - Cancer-selective apoptotic effects of extracellular and intracellular Par-4

AU - Shrestha-Bhattarai, T.

AU - Rangnekar, V. M.

N1 - Funding Information: This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).

PY - 2010/7/8

Y1 - 2010/7/8

N2 - Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

AB - Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

KW - Par-4

KW - apoptosis

KW - cell surface GRP78

UR - http://www.scopus.com/inward/record.url?scp=77954533130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954533130&partnerID=8YFLogxK

U2 - 10.1038/onc.2010.141

DO - 10.1038/onc.2010.141

M3 - Review article

C2 - 20440265

AN - SCOPUS:77954533130

SN - 0950-9232

VL - 29

SP - 3873

EP - 3880

JO - Oncogene

JF - Oncogene

IS - 27

ER -

Cancer-selective apoptotic effects of extracellular and intracellular Par-4

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this