Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.
|Number of pages||8|
|State||Published - Jul 8 2010|
Bibliographical noteFunding Information:
This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).
- cell surface GRP78
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research