Cancer-selective apoptotic effects of extracellular and intracellular Par-4

T. Shrestha-Bhattarai, V. M. Rangnekar

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

Original languageEnglish
Pages (from-to)3873-3880
Number of pages8
Issue number27
StatePublished - Jul 8 2010

Bibliographical note

Funding Information:
This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).


  • Par-4
  • apoptosis
  • cell surface GRP78

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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