Cancer-selective apoptotic effects of extracellular and intracellular Par-4

T. Shrestha-Bhattarai; V. M. Rangnekar

doi:10.1038/onc.2010.141

Cancer-selective apoptotic effects of extracellular and intracellular Par-4

T. Shrestha-Bhattarai, V. M. Rangnekar

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

Original language	English
Pages (from-to)	3873-3880
Number of pages	8
Journal	Oncogene
Volume	29
Issue number	27
DOIs	https://doi.org/10.1038/onc.2010.141
State	Published - Jul 8 2010

Bibliographical note

Funding Information:
This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).

Keywords

Par-4
apoptosis
cell surface GRP78

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/onc.2010.141

Cite this

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title = "Cancer-selective apoptotic effects of extracellular and intracellular Par-4",

abstract = "Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.",

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AU - Shrestha-Bhattarai, T.

AU - Rangnekar, V. M.

N1 - Funding Information: This study was supported by the NIH/NCI grants CA60872, CA105453 and CA84511 (to VMR).

PY - 2010/7/8

Y1 - 2010/7/8

N2 - Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

AB - Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

KW - Par-4

KW - apoptosis

KW - cell surface GRP78

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M3 - Review article

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VL - 29

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JO - Oncogene

JF - Oncogene

IS - 27

ER -

Cancer-selective apoptotic effects of extracellular and intracellular Par-4

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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