TY - JOUR
T1 - Cancer stem cells in the mechanism of metal carcinogenesis
AU - Wang, Lei
AU - Chen, Fei
AU - Zhang, Zhuo
AU - Chen, Gang
AU - Luo, Jia
AU - Shi, Xianglin
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Environmental metal carcinogenesis is a major public health concern. The mechanism underlying metal-induced carcinogenesis remains unclear. The concept of cancer stem cell recently has drawn considerable attention. Various studies indicate that the generation of cancer stem cells might contribute to the overall mechanism of development of metal-induced cancer. It is believed that oxidative stress and abnormal signaling caused by metals lead to the enrichment of cancer stem cells and eventually initiate cancer. In addition, metal-induced angiogenesis may also contribute to the generation of cancer stem cells. Studies using animal models further suggest that metals could induce the production of cancer stem cells and thus cause the development of cancer. This review summarizes recent studies of oxidative stress and cancer stem cells in relation to the mechanism of metal carcinogenesis.
AB - Environmental metal carcinogenesis is a major public health concern. The mechanism underlying metal-induced carcinogenesis remains unclear. The concept of cancer stem cell recently has drawn considerable attention. Various studies indicate that the generation of cancer stem cells might contribute to the overall mechanism of development of metal-induced cancer. It is believed that oxidative stress and abnormal signaling caused by metals lead to the enrichment of cancer stem cells and eventually initiate cancer. In addition, metal-induced angiogenesis may also contribute to the generation of cancer stem cells. Studies using animal models further suggest that metals could induce the production of cancer stem cells and thus cause the development of cancer. This review summarizes recent studies of oxidative stress and cancer stem cells in relation to the mechanism of metal carcinogenesis.
KW - Angiogenesis
KW - Cancer stem cell
KW - Carcinogenesis
KW - Metal
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=84872131211&partnerID=8YFLogxK
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U2 - 10.1615/JEnvironPatholToxicolOncol.v31.i3.60
DO - 10.1615/JEnvironPatholToxicolOncol.v31.i3.60
M3 - Article
C2 - 23339699
AN - SCOPUS:84872131211
SN - 0731-8898
VL - 31
SP - 245
EP - 263
JO - Journal of Environmental Pathology, Toxicology and Oncology
JF - Journal of Environmental Pathology, Toxicology and Oncology
IS - 3
ER -
