TY - JOUR
T1 - Cancer stem cells
T2 - Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance
AU - Adorno-Cruz, Valery
AU - Kibria, Golam
AU - Liu, Xia
AU - Doherty, Mary
AU - Junk, Damian J.
AU - Guan, Dongyin
AU - Hubert, Chris
AU - Venere, Monica
AU - Mulkearns-Hubert, Erin
AU - Sinyuk, Maksim
AU - Alvarado, Alvaro
AU - Caplan, Arnold I.
AU - Rich, Jeremy
AU - Gerson, Stanton L.
AU - Lathia, Justin
AU - Liu, Huiping
N1 - Publisher Copyright:
©2015 AACR.
PY - 2015/3/15
Y1 - 2015/3/15
N2 - With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer.
AB - With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer.
UR - http://www.scopus.com/inward/record.url?scp=84933283091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84933283091&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-14-3225
DO - 10.1158/0008-5472.CAN-14-3225
M3 - Article
C2 - 25604264
AN - SCOPUS:84933283091
SN - 0008-5472
VL - 75
SP - 924
EP - 929
JO - Cancer Research
JF - Cancer Research
IS - 6
ER -