Cannabinoid Receptors, Mental Pain and Suicidal Behavior: a Systematic Review

Laura Colino, Javier Herranz-Herrer, Elena Gil-Benito, Teresa Ponte-Lopez, Pablo del Sol-Calderon, Maria Rodrigo-Yanguas, María Gil-Ligero, Antonio J. Sánchez-López, Jose de Leon, Hilario Blasco-Fontecilla

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Purpose of Review: The current serotonin-based biological model of suicidal behavior (SB) may be too simplistic. There is emerging evidence that other biomarkers and biological systems may be involved in SB pathophysiology. The literature on the endocannabinoid (EC) systems and SB is limited. The objective of the present article is to review all available information on the relationship between cannabinoid receptors (CB1 and CB2 receptors), and SB and/or psychological pain. Recent Findings: Our review is limited by the small number and heterogeneity of studies identified: (1) an autopsy study describing elevated levels of CB1 receptor activity in the prefrontal cortex and suicide in both depression and alcoholism and (2) studies supporting the involvement of both CB1 and CB2 receptors in the regulation of neuropathic pain and stress-induced analgesia. Summary: We conclude that cannabinoid receptors, particularly CB1 receptors, may become promising targets for the development of novel therapeutic tools for the treatment of SB.

Original languageEnglish
Article number19
JournalCurrent Psychiatry Reports
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2018

Bibliographical note

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Cannabinoid receptors
  • Mental pain
  • Psychological pain
  • Suicidal behavior

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Cannabinoid Receptors, Mental Pain and Suicidal Behavior: a Systematic Review'. Together they form a unique fingerprint.

Cite this