TY - JOUR
T1 - Cannabinoid Receptors, Mental Pain and Suicidal Behavior
T2 - a Systematic Review
AU - Colino, Laura
AU - Herranz-Herrer, Javier
AU - Gil-Benito, Elena
AU - Ponte-Lopez, Teresa
AU - del Sol-Calderon, Pablo
AU - Rodrigo-Yanguas, Maria
AU - Gil-Ligero, María
AU - Sánchez-López, Antonio J.
AU - de Leon, Jose
AU - Blasco-Fontecilla, Hilario
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose of Review: The current serotonin-based biological model of suicidal behavior (SB) may be too simplistic. There is emerging evidence that other biomarkers and biological systems may be involved in SB pathophysiology. The literature on the endocannabinoid (EC) systems and SB is limited. The objective of the present article is to review all available information on the relationship between cannabinoid receptors (CB1 and CB2 receptors), and SB and/or psychological pain. Recent Findings: Our review is limited by the small number and heterogeneity of studies identified: (1) an autopsy study describing elevated levels of CB1 receptor activity in the prefrontal cortex and suicide in both depression and alcoholism and (2) studies supporting the involvement of both CB1 and CB2 receptors in the regulation of neuropathic pain and stress-induced analgesia. Summary: We conclude that cannabinoid receptors, particularly CB1 receptors, may become promising targets for the development of novel therapeutic tools for the treatment of SB.
AB - Purpose of Review: The current serotonin-based biological model of suicidal behavior (SB) may be too simplistic. There is emerging evidence that other biomarkers and biological systems may be involved in SB pathophysiology. The literature on the endocannabinoid (EC) systems and SB is limited. The objective of the present article is to review all available information on the relationship between cannabinoid receptors (CB1 and CB2 receptors), and SB and/or psychological pain. Recent Findings: Our review is limited by the small number and heterogeneity of studies identified: (1) an autopsy study describing elevated levels of CB1 receptor activity in the prefrontal cortex and suicide in both depression and alcoholism and (2) studies supporting the involvement of both CB1 and CB2 receptors in the regulation of neuropathic pain and stress-induced analgesia. Summary: We conclude that cannabinoid receptors, particularly CB1 receptors, may become promising targets for the development of novel therapeutic tools for the treatment of SB.
KW - Cannabinoid receptors
KW - Mental pain
KW - Psychological pain
KW - Suicidal behavior
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U2 - 10.1007/s11920-018-0880-4
DO - 10.1007/s11920-018-0880-4
M3 - Review article
C2 - 29546501
AN - SCOPUS:85044239320
SN - 1523-3812
VL - 20
JO - Current Psychiatry Reports
JF - Current Psychiatry Reports
IS - 3
M1 - 19
ER -
