Cannula design

Shaun D. Gregory, Jay Zwischenberger, Dongfang Wang, Sam Liao, Mark Slaughter

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The anatomical interaction between mechanical circulatory or respiratory support and the patient is achieved by specially designed tubes called cannulae. Despite advancements in cannula design for ventricular assist devices (VADs), extracorporeal membrane oxygenation (ECMO), and total artificial hearts (TAH), cannula-related complications such as bleeding and thrombus formation remain prevalent. There is no gold standard cannula design, with almost all clinically used devices incorporating a unique cannula design or placement. Inflow (flow from patient to device) and outflow (flow from device to patient) cannula design has focused on methods to deliver sufficient cardiac output, improve vessel flow dynamics, reduce postoperative bleeding, and other anatomical considerations. However, continued development of VAD, ECMO, and TAH cannula design is required to reduce postoperative complications and improve patient outcomes.

Original languageEnglish
Title of host publicationMechanical Circulatory and Respiratory Support
Number of pages30
ISBN (Electronic)9780128104927
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc. All rights reserved.


  • Cannula
  • Cuff
  • Extracorporeal membrane oxygenation
  • Graft
  • Total artificial heart
  • Ventricular assist device

ASJC Scopus subject areas

  • Engineering (all)
  • Biochemistry, Genetics and Molecular Biology (all)


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