Carbohydrate utilization by the Lyme borreliosis spirochete, Borrelia burgdorferi

Kate Von Lackum, Brian Stevenson

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Growth kinetic analyses of Borrelia burgdorferi indicated that this bacterium can utilize a limited number of carbon sources for energy: the monosaccharides glucose, mannose, and N-acetylglucosamine, the disaccharides maltose and chitobiose, and glycerol. All of these carbohydrates are likely to be available to B. burgdorferi during infection of either vertebrate and arthropod hosts, enabling development of a model describing energy sources potentially used by the Lyme borreliosis spirochete during its natural infectious cycle.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalFEMS Microbiology Letters
Volume243
Issue number1
DOIs
StatePublished - Feb 1 2005

Bibliographical note

Funding Information:
These studies were supported by US Public Health Service Grants R01-AI53101 and 5T32-AI49795. We thank Jennifer Miller for advice on growth curve assays; Frank Gherardini, Kit Tilly, Rebecca Byram and Patricia Rosa for constructive discussions of biochemical pathways and B. burgdorferi biology; and Kelly Babb and Sara Bair for technical assistance.

Keywords

  • Borrelia burgdorferi
  • Carbohydrate utilization
  • Lyme borreliosis
  • Lyme disease
  • Spirochete

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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