Carbon nanotube aqueous sol-gel composites: Enzyme-friendly platforms for the development of stable biosensors

Vasilis G. Gavalas; Stacy A. Law; J. Christopher Ball; Rodney Andrews; Leonidas G. Bachas

doi:10.1016/j.ab.2004.02.025

Carbon nanotube aqueous sol-gel composites: Enzyme-friendly platforms for the development of stable biosensors

Vasilis G. Gavalas, Stacy A. Law, J. Christopher Ball, Rodney Andrews, Leonidas G. Bachas

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

A new type of composite material based on carbon nanotubes and an aqueous sol-gel process has been developed. The electrochemical characteristics of these composites were investigated and compared to composites made with an alkoxy silane sol-gel process. The use of carbon nanotubes, as the conductive part of the composite, facilitated fast electron transfer rates. The feasibility of this type of composite for the development of biosensors was demonstrated using L-amino acid oxidase. The stability of the enzyme was increased when it was encapsulated in the aqueous sol-gel, and the sensor retained more that 50% of its response after 1 month of testing.

Original language	English
Pages (from-to)	247-252
Number of pages	6
Journal	Analytical Biochemistry
Volume	329
Issue number	2
DOIs	https://doi.org/10.1016/j.ab.2004.02.025
State	Published - Jun 15 2004

Bibliographical note

Funding Information:
This work was funded by the National Aeronautics and Space Administration and by the National Science Foundation, Division of Materials Research under Grant No. DMR-9809686. S. Law thanks NSF-REU program (DMR-0097692) for financial support.

Keywords

Aqueous sol-gels
Biosensor
Carbon nanotubes
Composite electrodes
Enzyme stability

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.ab.2004.02.025

Cite this

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title = "Carbon nanotube aqueous sol-gel composites: Enzyme-friendly platforms for the development of stable biosensors",

abstract = "A new type of composite material based on carbon nanotubes and an aqueous sol-gel process has been developed. The electrochemical characteristics of these composites were investigated and compared to composites made with an alkoxy silane sol-gel process. The use of carbon nanotubes, as the conductive part of the composite, facilitated fast electron transfer rates. The feasibility of this type of composite for the development of biosensors was demonstrated using L-amino acid oxidase. The stability of the enzyme was increased when it was encapsulated in the aqueous sol-gel, and the sensor retained more that 50% of its response after 1 month of testing.",

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note = "Funding Information: This work was funded by the National Aeronautics and Space Administration and by the National Science Foundation, Division of Materials Research under Grant No. DMR-9809686. S. Law thanks NSF-REU program (DMR-0097692) for financial support.",

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AU - Law, Stacy A.

AU - Ball, J. Christopher

AU - Andrews, Rodney

AU - Bachas, Leonidas G.

N1 - Funding Information: This work was funded by the National Aeronautics and Space Administration and by the National Science Foundation, Division of Materials Research under Grant No. DMR-9809686. S. Law thanks NSF-REU program (DMR-0097692) for financial support.

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KW - Carbon nanotubes

KW - Composite electrodes

KW - Enzyme stability

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Carbon nanotube aqueous sol-gel composites: Enzyme-friendly platforms for the development of stable biosensors

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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