Cardiac cell therapy: Insights into the mechanisms of tissue repair

Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Ahmed Abdel-Latif

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

Original languageEnglish
Article number1201
Pages (from-to)1-15
Number of pages15
JournalInternational Journal of Molecular Sciences
Issue number3
StatePublished - Feb 1 2021

Bibliographical note

Funding Information:
Funding: Abdel-Latif is supported by NIH Grant R01 HL124266. Hsuan Peng is supported by NIH F99 fellowship AG068525.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Heart failure
  • Inflammation
  • Mesenchymal stem cells
  • Myocardial infarction
  • Stem cell therapy

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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