Cardiac cell therapy: Insights into the mechanisms of tissue repair

Hsuan Peng; Kazuhiro Shindo; Renée R. Donahue; Ahmed Abdel-Latif

doi:10.3390/ijms22031201

Cardiac cell therapy: Insights into the mechanisms of tissue repair

Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Ahmed Abdel-Latif

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

Original language	English
Article number	1201
Pages (from-to)	1-15
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	3
DOIs	https://doi.org/10.3390/ijms22031201
State	Published - Feb 1 2021

Bibliographical note

Funding Information:
Funding: Abdel-Latif is supported by NIH Grant R01 HL124266. Hsuan Peng is supported by NIH F99 fellowship AG068525.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Heart failure
Inflammation
Mesenchymal stem cells
Myocardial infarction
Stem cell therapy

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms22031201

Cite this

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abstract = "Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.",

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author = "Hsuan Peng and Kazuhiro Shindo and Donahue, {Ren{\'e}e R.} and Ahmed Abdel-Latif",

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AU - Donahue, Renée R.

AU - Abdel-Latif, Ahmed

N1 - Funding Information: Funding: Abdel-Latif is supported by NIH Grant R01 HL124266. Hsuan Peng is supported by NIH F99 fellowship AG068525. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

AB - Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

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Cardiac cell therapy: Insights into the mechanisms of tissue repair

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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