Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults

Nathan F. Johnson; Brian T. Gold; Alison L. Bailey; Jody L. Clasey; Jonathan G. Hakun; Matthew White; Doug E. Long; David K. Powell

doi:10.1016/j.neuroimage.2015.05.063

Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults

Nathan F. Johnson, Brian T. Gold, Alison L. Bailey, Jody L. Clasey, Jonathan G. Hakun, Matthew White, Doug E. Long, David K. Powell

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A growing body of evidence indicates that cardiorespiratory fitness attenuates some age-related cerebral declines. However, little is known about the role that myocardial function plays in this relationship. Brain regions with high resting metabolic rates, such as the default mode network (DMN), may be especially vulnerable to age-related declines in myocardial functions affecting cerebral blood flow (CBF). This study explored the relationship between a measure of myocardial mechanics, global longitudinal strain (GLS), and CBF to the DMN. In addition, we explored how cardiorespiratory affects this relationship. Participants were 30 older adults between the ages of 59 and 69 (mean age = 63.73 years, SD = 2.8). Results indicated that superior cardiorespiratory fitness and myocardial mechanics were positively associated with DMN CBF. Moreover, results of a mediation analysis revealed that the relationship between GLS and DMN CBF was accounted for by individual differences in fitness. Findings suggest that benefits of healthy heart function to brain function are modified by fitness.

Original language	English
Pages (from-to)	126-132
Number of pages	7
Journal	NeuroImage
Volume	131
DOIs	https://doi.org/10.1016/j.neuroimage.2015.05.063
State	Published - May 1 2016

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Funding

This study was supported by the National Institutes of Health CTSA UL1TR000117 and the University of Kentucky's Clinical Services Core (CSC). Specifically we would like to thank the Translational Analytics and Assessment Support (TAAS) lab for collecting all fitness-related measures. The content is solely the responsibility of the authors and does not necessarily represent the official views of these granting agencies.

Funders	Funder number
University of Kentucky's Clinical Services Core
National Institutes of Health (NIH)	CTSA UL1TR000117
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)	KL2TR000116
National Center for Advancing Translational Sciences (NCATS)
China Scholarship Council

Keywords

Aging
Arterial spin labeling
Cardiorespiratory fitness
Default mode network
Global longitudinal strain

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2015.05.063

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title = "Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults",

abstract = "A growing body of evidence indicates that cardiorespiratory fitness attenuates some age-related cerebral declines. However, little is known about the role that myocardial function plays in this relationship. Brain regions with high resting metabolic rates, such as the default mode network (DMN), may be especially vulnerable to age-related declines in myocardial functions affecting cerebral blood flow (CBF). This study explored the relationship between a measure of myocardial mechanics, global longitudinal strain (GLS), and CBF to the DMN. In addition, we explored how cardiorespiratory affects this relationship. Participants were 30 older adults between the ages of 59 and 69 (mean age = 63.73 years, SD = 2.8). Results indicated that superior cardiorespiratory fitness and myocardial mechanics were positively associated with DMN CBF. Moreover, results of a mediation analysis revealed that the relationship between GLS and DMN CBF was accounted for by individual differences in fitness. Findings suggest that benefits of healthy heart function to brain function are modified by fitness.",

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AU - Bailey, Alison L.

AU - Clasey, Jody L.

AU - Hakun, Jonathan G.

AU - White, Matthew

AU - Long, Doug E.

AU - Powell, David K.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - A growing body of evidence indicates that cardiorespiratory fitness attenuates some age-related cerebral declines. However, little is known about the role that myocardial function plays in this relationship. Brain regions with high resting metabolic rates, such as the default mode network (DMN), may be especially vulnerable to age-related declines in myocardial functions affecting cerebral blood flow (CBF). This study explored the relationship between a measure of myocardial mechanics, global longitudinal strain (GLS), and CBF to the DMN. In addition, we explored how cardiorespiratory affects this relationship. Participants were 30 older adults between the ages of 59 and 69 (mean age = 63.73 years, SD = 2.8). Results indicated that superior cardiorespiratory fitness and myocardial mechanics were positively associated with DMN CBF. Moreover, results of a mediation analysis revealed that the relationship between GLS and DMN CBF was accounted for by individual differences in fitness. Findings suggest that benefits of healthy heart function to brain function are modified by fitness.

AB - A growing body of evidence indicates that cardiorespiratory fitness attenuates some age-related cerebral declines. However, little is known about the role that myocardial function plays in this relationship. Brain regions with high resting metabolic rates, such as the default mode network (DMN), may be especially vulnerable to age-related declines in myocardial functions affecting cerebral blood flow (CBF). This study explored the relationship between a measure of myocardial mechanics, global longitudinal strain (GLS), and CBF to the DMN. In addition, we explored how cardiorespiratory affects this relationship. Participants were 30 older adults between the ages of 59 and 69 (mean age = 63.73 years, SD = 2.8). Results indicated that superior cardiorespiratory fitness and myocardial mechanics were positively associated with DMN CBF. Moreover, results of a mediation analysis revealed that the relationship between GLS and DMN CBF was accounted for by individual differences in fitness. Findings suggest that benefits of healthy heart function to brain function are modified by fitness.

KW - Aging

KW - Arterial spin labeling

KW - Cardiorespiratory fitness

KW - Default mode network

KW - Global longitudinal strain

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Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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