Cardiovascular devices and platelet interactions understanding the role of injury, flow, and cellular responses

Jesse W. Rowley, Aloke V. Finn, Patricia A. French, Lisa K. Jennings, Danny Bluestein, Peter L. Gross, Jane E. Freedman, Steven R. Steinhubl, Guy A. Zimmerman, Richard C. Becker, Harold L. Dauerman, Susan S. Smyth

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Shear influences platelet adhesion and activation through mechanisms that include altering vWF binding and IIb3/ purinergic signaling interactions. Shear can potentially promote inflammation and atherogenesis through plateletmediated processes. New methods to study platelet function under shear conditions and in more physiological contexts should be incorporated to guide the design of future devices and drug therapies. Some of these methods include in vivo imaging, in vitro flow models, and in vitro modeling/ computer-assisted iterative device design. Improving currently used antiplatelet agents is not the sole answer for reducing vascular injury after PCI. Cilostazol and statins are promising examples of agents that have effects beyond inhibition of platelet activation. In addition, LST, which has been associated with both stent design and pathological changes (such as endothelialization and neoatherosclerosis within the neointima), is becoming a less critical issue with DES because of the use of DAPT and newer stent designs.

Original languageEnglish
Pages (from-to)296-304
Number of pages9
JournalCirculation: Cardiovascular Interventions
Volume5
Issue number2
DOIs
StatePublished - Apr 2012

Keywords

  • Blood flow
  • Platelets
  • Shear
  • Stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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