Abstract
Androgen deprivation therapy is a cornerstone of prostate cancer treatment. Pharmacological androgen deprivation includes gonadotropin-releasing hormone agonism and antagonism, androgen receptor inhibition, and CYP17 (cytochrome P450 17A1) inhibition. Studies in the past decade have raised concerns about the potential for androgen deprivation therapy to increase the risk of adverse cardiovascular events such as myocardial infarction, stroke, and cardiovascular mortality, possibly by exacerbating cardiovascular risk factors. In this review, we summarize existing data on the cardiovascular effects of androgen deprivation therapy. Among the therapies, abiraterone stands out for increasing risk of cardiac events in meta-analyses of both randomized controlled trials and observational studies. We find a divergence between observational studies, which show consistent positive associations between androgen deprivation therapy use and cardiovascular disease, and randomized controlled trials, which do not show these associations reproducibly.
| Original language | English |
|---|---|
| Pages (from-to) | E55-E64 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 40 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2020 |
Bibliographical note
Funding Information:This work was supported by National Institute of Health grants R56HL141466 and R01HL141466. W.C. Meijers was supported by funding from the Niels Stensen Fellowship and the Netherlands Heart Institute.
Publisher Copyright:
© 2020 American Heart Association, Inc.
Keywords
- androgen deprivation therapy
- cardiooncology
- cardiotoxicity
- gonadotropin releasing hormone agonists
- prostate cancer
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
