Cardiovascular Health and Incident Cardiovascular Disease and Cancer: The Women's Health Initiative

Randi E. Foraker, Mahmoud Abdel-Rasoul, Lewis H. Kuller, Rebecca D. Jackson, Linda Van Horn, Rebecca A. Seguin, Monika M. Safford, Robert B. Wallace, Anna M. Kucharska-Newton, Jennifer G. Robinson, Lisa W. Martin, Golareh Agha, Lifang Hou, Norrina B. Allen, Hilary A. Tindle

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Introduction The American Heart Association's "Simple 7" offers a practical public health conceptualization of cardiovascular health (CVH). CVH predicts incident cardiovascular disease (CVD) in younger populations, but has not been studied in a large, diverse population of aging postmenopausal women. The extent to which CVH predicts cancer in postmenopausal women is unknown. Methods Multivariable Cox regression estimated hazard ratios and 95% CIs for the association between CVH and incident CVD, any cancer, and cancer subtypes (lung, colorectal, and breast) among 161,809 Women's Health Initiative observational study and clinical trial participants followed from 1993 through 2010. Data were analyzed in 2013. CVH score was characterized as the number (0 [worst] to 7 [best]) of the American Heart Association's ideal CVH behaviors and factors at baseline: smoking, BMI, physical activity, diet, total cholesterol, blood pressure, and fasting glucose. Results Median follow-up was approximately 13 years. Fewer minorities and less educated women achieved ideal CVH, a common benchmark. In adjusted models, compared with women with the highest (best) CVH scores, those with the lowest (worst) CVH scores had nearly seven times the hazard of incident CVD (6.83, 95% CI=5.83, 8.00) and 52% greater risk of incident cancer (1.52, 95% CI=1.35, 1.72). Ideal CVH was most strongly inversely associated with lung cancer, then colorectal cancer, and then breast cancer. Conclusions Lower ideal CVH is more common among minority and less educated postmenopausal women and predicts increased risk of CVD and cancer in this population, emphasizing the importance of prevention efforts among vulnerable older adults.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalAmerican Journal of Preventive Medicine
Issue number2
StatePublished - Feb 1 2016

Bibliographical note

Publisher Copyright:
© 2016 American Journal of Preventive Medicine.

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health


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