Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.
|Number of pages||4|
|Journal||American Journal of the Medical Sciences|
|State||Published - 1993|
Bibliographical noteFunding Information:
From Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis, Indiana. Dr. Rudy is a recipient of a Pharmaceutical Manufacturers Association Foundation Fellowship Award for clinical pharmacology. Correspondence: Barry F. Krieble, MD, Nephrology Section, Indiana University School of Medicine, Fesler Hall, Room 108, 1120 South Drive, Indianapolis, IN 46202-5116.
- Acute renal failure
ASJC Scopus subject areas
- Medicine (all)