Case report: Acyclovir neurotoxicity and nephrotoxicity - The role for hemodialysis

B. F. Krieble, D. W. Rudy, M. R. Glick, M. D. Clayman

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalAmerican Journal of the Medical Sciences
Issue number1
StatePublished - 1993

Bibliographical note

Funding Information:
From Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis, Indiana. Dr. Rudy is a recipient of a Pharmaceutical Manufacturers Association Foundation Fellowship Award for clinical pharmacology. Correspondence: Barry F. Krieble, MD, Nephrology Section, Indiana University School of Medicine, Fesler Hall, Room 108, 1120 South Drive, Indianapolis, IN 46202-5116.


  • Acute renal failure
  • Acyclovir
  • Crystalluria
  • Hemodialysis
  • Nephrotoxicity
  • Neurotoxicity

ASJC Scopus subject areas

  • General Medicine


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