Abstract
Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.
Original language | English |
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Pages (from-to) | 36-39 |
Number of pages | 4 |
Journal | American Journal of the Medical Sciences |
Volume | 305 |
Issue number | 1 |
DOIs | |
State | Published - 1993 |
Bibliographical note
Funding Information:From Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis, Indiana. Dr. Rudy is a recipient of a Pharmaceutical Manufacturers Association Foundation Fellowship Award for clinical pharmacology. Correspondence: Barry F. Krieble, MD, Nephrology Section, Indiana University School of Medicine, Fesler Hall, Room 108, 1120 South Drive, Indianapolis, IN 46202-5116.
Funding
From Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis, Indiana. Dr. Rudy is a recipient of a Pharmaceutical Manufacturers Association Foundation Fellowship Award for clinical pharmacology. Correspondence: Barry F. Krieble, MD, Nephrology Section, Indiana University School of Medicine, Fesler Hall, Room 108, 1120 South Drive, Indianapolis, IN 46202-5116.
Funders | Funder number |
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Pharmaceutical Manufacturers Association Foundation |
Keywords
- Acute renal failure
- Acyclovir
- Crystalluria
- Hemodialysis
- Nephrotoxicity
- Neurotoxicity
ASJC Scopus subject areas
- General Medicine