Case report: Acyclovir neurotoxicity and nephrotoxicity - The role for hemodialysis

B. F. Krieble; D. W. Rudy; M. R. Glick; M. D. Clayman

doi:10.1097/00000441-199301000-00007

Case report: Acyclovir neurotoxicity and nephrotoxicity - The role for hemodialysis

B. F. Krieble
, D. W. Rudy
, M. R. Glick
, M. D. Clayman

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	American Journal of the Medical Sciences
Volume	305
Issue number	1
DOIs	https://doi.org/10.1097/00000441-199301000-00007
State	Published - 1993

Bibliographical note

Funding Information:
From Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis, Indiana. Dr. Rudy is a recipient of a Pharmaceutical Manufacturers Association Foundation Fellowship Award for clinical pharmacology. Correspondence: Barry F. Krieble, MD, Nephrology Section, Indiana University School of Medicine, Fesler Hall, Room 108, 1120 South Drive, Indianapolis, IN 46202-5116.

Funding

From Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis, Indiana. Dr. Rudy is a recipient of a Pharmaceutical Manufacturers Association Foundation Fellowship Award for clinical pharmacology. Correspondence: Barry F. Krieble, MD, Nephrology Section, Indiana University School of Medicine, Fesler Hall, Room 108, 1120 South Drive, Indianapolis, IN 46202-5116.

Funders
Pharmaceutical Manufacturers Association Foundation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute renal failure
Acyclovir
Crystalluria
Hemodialysis
Nephrotoxicity
Neurotoxicity

ASJC Scopus subject areas

General Medicine

Access to Document

10.1097/00000441-199301000-00007

Cite this

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AU - Glick, M. R.

AU - Clayman, M. D.

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KW - Crystalluria

KW - Hemodialysis

KW - Nephrotoxicity

KW - Neurotoxicity

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Case report: Acyclovir neurotoxicity and nephrotoxicity - The role for hemodialysis

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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