TY - JOUR
T1 - Case Report
T2 - Safety and Efficacy of Enfortumab Vedotin in a Patient With Metastatic Urothelial Carcinoma Undergoing Peritoneal Dialysis
AU - Collette, Kaylyn R.
AU - Myint, Zin W.
AU - Parasramka, Saurabh V.
AU - Ellis, Carleton S.
N1 - Publisher Copyright:
Copyright © 2022 Collette, Myint, Parasramka and Ellis.
PY - 2022/5/25
Y1 - 2022/5/25
N2 - The clinical management of metastatic urothelial carcinoma has significantly evolved with the emergence of monoclonal antibodies and antibody-drug conjugates (ADCs). Enfortumab vedotin (EV) was granted approval by the FDA in 2021 for patients with locally advanced or metastatic urothelial carcinoma who have received prior immunotherapy and platinum-containing chemotherapy. Little to no data exist for the use of EV in patients with concurrent end-stage renal disease (ESRD) using either hemodialysis or peritoneal dialysis (PD). Here, we present the case of a patient with metastatic urothelial carcinoma on PD who failed multiple lines of treatment but demonstrated an impressive response to EV without significant toxicity. We discuss the possible impact of peritoneal dialysis on the pharmacokinetics of ADCs and the potential for safe administration based on known pharmacokinetic data.
AB - The clinical management of metastatic urothelial carcinoma has significantly evolved with the emergence of monoclonal antibodies and antibody-drug conjugates (ADCs). Enfortumab vedotin (EV) was granted approval by the FDA in 2021 for patients with locally advanced or metastatic urothelial carcinoma who have received prior immunotherapy and platinum-containing chemotherapy. Little to no data exist for the use of EV in patients with concurrent end-stage renal disease (ESRD) using either hemodialysis or peritoneal dialysis (PD). Here, we present the case of a patient with metastatic urothelial carcinoma on PD who failed multiple lines of treatment but demonstrated an impressive response to EV without significant toxicity. We discuss the possible impact of peritoneal dialysis on the pharmacokinetics of ADCs and the potential for safe administration based on known pharmacokinetic data.
KW - antibody–drug conjugate
KW - end-stage renal disease
KW - enfortumab vedotin
KW - metastatic urothelial carcinoma
KW - peritoneal dialysis
UR - http://www.scopus.com/inward/record.url?scp=85131876076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85131876076&partnerID=8YFLogxK
U2 - 10.3389/fonc.2022.892793
DO - 10.3389/fonc.2022.892793
M3 - Article
AN - SCOPUS:85131876076
SN - 2234-943X
VL - 12
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 892793
ER -
