Case report: Synephrine, a plant substance yielding classic environmental clusters of hay related identifications in equine urine

Kimberly Brewer; Jacob Joseph Machin; George Maylin; Clara Fenger; Abelardo Morales-Briceño; Martina M. Neidhart; Thomas Tobin

doi:10.1002/dta.3212

Case report: Synephrine, a plant substance yielding classic environmental clusters of hay related identifications in equine urine

Kimberly Brewer, Jacob Joseph Machin, George Maylin, Clara Fenger, Abelardo Morales-Briceño, Martina M. Neidhart, Thomas Tobin

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Original language	English
Pages (from-to)	774-780
Number of pages	7
Journal	Drug Testing and Analysis
Volume	14
Issue number	4
DOIs	https://doi.org/10.1002/dta.3212
State	Published - Apr 2022

Bibliographical note

Funding Information:
This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58-6401-2-0025 for Forage-Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky. The funding sources provided no role in the design of the study, nor in the collection, analysis, and interpretation of the data and writing of the manuscript.

Funding Information:
This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58‐6401‐2‐0025 for Forage‐Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky.

Funding

This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58-6401-2-0025 for Forage-Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky. The funding sources provided no role in the design of the study, nor in the collection, analysis, and interpretation of the data and writing of the manuscript. This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58‐6401‐2‐0025 for Forage‐Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky.

Funders	Funder number
COMMONWEALTH OF KENTUCKY
Department of Veterinary Science, University of Kentucky
Kentucky Department of Agriculture
Kentucky Thoroughbred Association Foundation
National Horsemen's
United States Trotting Association
West Virginia Horsemen's
U.S. Department of Agriculture	KY014051, 1010609
National Institute of Food and Agriculture
USDA-Agricultural Research Service	58‐6401‐2‐0025
Kentucky Agricultural Experiment Station
COMMONWEALTH OF KENTUCKY

ASJC Scopus subject areas

Analytical Chemistry
Environmental Chemistry
Pharmaceutical Science
Spectroscopy

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10.1002/dta.3212

Cite this

@article{5d7acd636b3847d89c0faf8d2682c799,

title = "Case report: Synephrine, a plant substance yielding classic environmental clusters of hay related identifications in equine urine",

author = "Kimberly Brewer and Machin, {Jacob Joseph} and George Maylin and Clara Fenger and Abelardo Morales-Brice{\~n}o and Neidhart, {Martina M.} and Thomas Tobin",

note = "Funding Information: This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58-6401-2-0025 for Forage-Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky. The funding sources provided no role in the design of the study, nor in the collection, analysis, and interpretation of the data and writing of the manuscript. Funding Information: This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58‐6401‐2‐0025 for Forage‐Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky. ",

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AU - Maylin, George

AU - Fenger, Clara

AU - Morales-Briceño, Abelardo

AU - Neidhart, Martina M.

AU - Tobin, Thomas

N1 - Funding Information: This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58-6401-2-0025 for Forage-Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky. The funding sources provided no role in the design of the study, nor in the collection, analysis, and interpretation of the data and writing of the manuscript. Funding Information: This research was made possible by research support from the Equine Health and Welfare Alliance, Inc, Versailles, Kentucky, and the United States Trotting Association, Columbus, Ohio. Further support came from the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch Program under project KY014051 Accession Number 1010609, and also by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58‐6401‐2‐0025 for Forage‐Animal Production Research, the Kentucky Department of Agriculture, and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support includes research support from the National Horsemen's Benevolent and Protective Association and the Alabama, Arizona, Arkansas, Ontario, Canada; Charles Town, WV; Florida, Indiana, Iowa, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Ohio, Oklahoma, Oregon, Pennsylvania, Tampa Bay Downs, Florida, Texas, Washington State, and West Virginia Horsemen's Benevolent and Protective Associations. Published as paper #504 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky.

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Case report: Synephrine, a plant substance yielding classic environmental clusters of hay related identifications in equine urine

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

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