Case series of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy during extracorporeal life support

Prasad Bhandary; John M. Daniel; Sean C. Skinner; Matthew K. Bacon; Mina Hanna; John A. Bauer; Peter Giannone; Hubert O. Ballard

doi:10.1177/0267659119899521

Case series of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy during extracorporeal life support

Prasad Bhandary, John M. Daniel, Sean C. Skinner, Matthew K. Bacon, Mina Hanna, John A. Bauer, Peter Giannone, Hubert O. Ballard

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Therapeutic hypothermia initiated within 6 hours of birth is currently the standard of care for the management of neonates with hypoxic-ischemic encephalopathy. Neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy are also at risk for severe respiratory failure and need for extracorporeal life support. The risks and benefits of therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support are still not well defined. We report our experience of a case series of six neonates who underwent therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support. We also report long-term neurodevelopmental follow-up from 6 to 24 months and add to the current body of evidence regarding feasibility, clinical experience, and short-term complications.

Original language	English
Pages (from-to)	700-706
Number of pages	7
Journal	Perfusion (United Kingdom)
Volume	35
Issue number	7
DOIs	https://doi.org/10.1177/0267659119899521
State	Published - Oct 1 2020

Bibliographical note

Publisher Copyright:
© The Author(s) 2020.

Funding

Funders	Funder number
Eunice Kennedy Shriver National Institute of Child Health and Human Development	R01HD070792

Keywords

extracorporeal life support
hypoxic-ischemic encephalopathy
neonatal encephalopathy
therapeutic hypothermia

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Safety Research
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

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10.1177/0267659119899521

Cite this

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title = "Case series of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy during extracorporeal life support",

abstract = "Therapeutic hypothermia initiated within 6 hours of birth is currently the standard of care for the management of neonates with hypoxic-ischemic encephalopathy. Neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy are also at risk for severe respiratory failure and need for extracorporeal life support. The risks and benefits of therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support are still not well defined. We report our experience of a case series of six neonates who underwent therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support. We also report long-term neurodevelopmental follow-up from 6 to 24 months and add to the current body of evidence regarding feasibility, clinical experience, and short-term complications.",

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AU - Bhandary, Prasad

AU - Daniel, John M.

AU - Skinner, Sean C.

AU - Bacon, Matthew K.

AU - Hanna, Mina

AU - Bauer, John A.

AU - Giannone, Peter

AU - Ballard, Hubert O.

N1 - Publisher Copyright: © The Author(s) 2020.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Therapeutic hypothermia initiated within 6 hours of birth is currently the standard of care for the management of neonates with hypoxic-ischemic encephalopathy. Neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy are also at risk for severe respiratory failure and need for extracorporeal life support. The risks and benefits of therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support are still not well defined. We report our experience of a case series of six neonates who underwent therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support. We also report long-term neurodevelopmental follow-up from 6 to 24 months and add to the current body of evidence regarding feasibility, clinical experience, and short-term complications.

AB - Therapeutic hypothermia initiated within 6 hours of birth is currently the standard of care for the management of neonates with hypoxic-ischemic encephalopathy. Neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy are also at risk for severe respiratory failure and need for extracorporeal life support. The risks and benefits of therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support are still not well defined. We report our experience of a case series of six neonates who underwent therapeutic hypothermia for hypoxic-ischemic encephalopathy during extracorporeal life support. We also report long-term neurodevelopmental follow-up from 6 to 24 months and add to the current body of evidence regarding feasibility, clinical experience, and short-term complications.

KW - extracorporeal life support

KW - hypoxic-ischemic encephalopathy

KW - neonatal encephalopathy

KW - therapeutic hypothermia

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Case series of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy during extracorporeal life support

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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