Ca2+ -calmodulin-dependent protein kinase in neuronal nuclei

N. Sahyoun, H. LeVine, D. Bronson, P. Cuatrecasas

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Ca2+ -calmodulin-dependent protein kinase represents a major enzyme activity in neuronal nuclei. Most of the protein kinase activity is associated with the nuclear matrix but it can phosphorylate a broad range of substrates which derive from different nuclear compartments. Notable among these substrates is a M(r) = 50,000 component of the nuclear matrix and a high mobility group chromatin protein which behaves like HMG17. The high level of activity, age- and tissue-specificity, and sensitivity to low concentrations of calmodulin suggest a role for this Ca2+-calmodulin-dependent protein kinase in regulating a neuronal function at the level of the nucleus.

Original languageEnglish
Pages (from-to)9341-9344
Number of pages4
JournalJournal of Biological Chemistry
Issue number15
StatePublished - 1984

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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