Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.
|Number of pages||5|
|Journal||Trends in Cardiovascular Medicine|
|State||Published - Apr 2005|
Bibliographical noteFunding Information:
The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine