Caveolae, lipid rafts, and vascular disease

Xiang An Li; William V. Everson; Eric J. Smart

doi:10.1016/j.tcm.2005.04.001

Caveolae, lipid rafts, and vascular disease

Xiang An Li, William V. Everson, Eric J. Smart

Physiology

Research output: Contribution to journal › Review article › peer-review

87 Scopus citations

Abstract

Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.

Original language	English
Pages (from-to)	92-96
Number of pages	5
Journal	Trends in Cardiovascular Medicine
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.tcm.2005.04.001
State	Published - Apr 2005

Bibliographical note

Funding Information:
The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.tcm.2005.04.001

Cite this

@article{faadcfd121e04964ab02d1b36c69ea57,

title = "Caveolae, lipid rafts, and vascular disease",

abstract = "Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.",

author = "Li, {Xiang An} and Everson, {William V.} and Smart, {Eric J.}",

note = "Funding Information: The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).",

year = "2005",

month = apr,

doi = "10.1016/j.tcm.2005.04.001",

language = "English",

volume = "15",

pages = "92--96",

number = "3",

}

TY - JOUR

T1 - Caveolae, lipid rafts, and vascular disease

AU - Li, Xiang An

AU - Everson, William V.

AU - Smart, Eric J.

N1 - Funding Information: The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).

PY - 2005/4

Y1 - 2005/4

N2 - Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.

AB - Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.

UR - http://www.scopus.com/inward/record.url?scp=22544443358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22544443358&partnerID=8YFLogxK

U2 - 10.1016/j.tcm.2005.04.001

DO - 10.1016/j.tcm.2005.04.001

M3 - Review article

C2 - 16039968

AN - SCOPUS:22544443358

SN - 1050-1738

VL - 15

SP - 92

EP - 96

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 3

ER -

Caveolae, lipid rafts, and vascular disease

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this