Caveolae, lipid rafts, and vascular disease

Xiang An Li, William V. Everson, Eric J. Smart

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalTrends in Cardiovascular Medicine
Issue number3
StatePublished - Apr 2005

Bibliographical note

Funding Information:
The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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