TY - JOUR
T1 - CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells
AU - Bikah, Gabriel
AU - Carey, Jacqueline
AU - Ciallella, John R.
AU - Tarakhovsky, Alexander
AU - Bondada, Subbarao
PY - 1996/12/13
Y1 - 1996/12/13
N2 - A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo apoptosis. However, in CD5-deficient mice, B-1 cells responded to mIgM crosslinking by developing a resistance to apoptosis and entering the cell cycle. In wild-type B-1 cells, prevention of association between CD5 and mIgM rescued their growth response to mIgM crosslinking. Thus the B cell receptor-mediated signaling is negatively regulated by CD5 in normal B-1 cells.
AB - A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo apoptosis. However, in CD5-deficient mice, B-1 cells responded to mIgM crosslinking by developing a resistance to apoptosis and entering the cell cycle. In wild-type B-1 cells, prevention of association between CD5 and mIgM rescued their growth response to mIgM crosslinking. Thus the B cell receptor-mediated signaling is negatively regulated by CD5 in normal B-1 cells.
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U2 - 10.1126/science.274.5294.1906
DO - 10.1126/science.274.5294.1906
M3 - Article
C2 - 8943203
AN - SCOPUS:0030474683
SN - 0036-8075
VL - 274
SP - 1906
EP - 1909
JO - Science
JF - Science
IS - 5294
ER -