Abstract
CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.
| Original language | English |
|---|---|
| Pages (from-to) | 2855-2861 |
| Number of pages | 7 |
| Journal | World Journal of Gastroenterology |
| Volume | 15 |
| Issue number | 23 |
| DOIs | |
| State | Published - Jun 21 2009 |
Funding
| Funders | Funder number |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases | R01DK050669 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- CD74
- Cancer
- Gastrointestinal tract
- Helicobacter pylori
- Inflammation
- Invariant chain
ASJC Scopus subject areas
- Gastroenterology
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