Our previous study demonstrated that CD8+ T cells remove cysts of Toxoplasma gondii from the brain through perforin-mediated mechanisms. We here show that a transfer of CD8+ immune T cells primed with a type II or a type III strain of T. gondii both efficiently removed cysts of a type II strain from infected SCID mice, although the former tended to be slightly more efficient than the latter. Similarly, a transfer of type II-primed CD8+ T cells removed cysts of a type III strain. Therefore, CD8+ T cells are capable of removing T. gondii cysts by recognizing epitopes commonly expressed in types II and III strains or cross-reactive between these two genotypes.
|Number of pages||6|
|Journal||Microbes and Infection|
|State||Published - Jul 1 2016|
Bibliographical noteFunding Information:
The studies are supported in part by NIH grants ( AI095032 , AI073576 , and AI078756 ) (Y.S.). This work was also supported, in part, by the Intramural Research Program of the National Institutes of Health, NIAID (M.E.G.) . M.E.G. is a Scholar of the Canadian Institute for Advanced Research (CIFAR) Integrated Microbial Biodiversity program.
- CD8 T cells
- Toxoplasma gondii
ASJC Scopus subject areas
- Infectious Diseases