CD8+ T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite

Eri Ochiai; Qila Sa; Sara Perkins; Michael E. Grigg; Yasuhiro Suzuki

doi:10.1016/j.micinf.2016.03.013

CD8⁺ T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite

Eri Ochiai, Qila Sa, Sara Perkins, Michael E. Grigg, Yasuhiro Suzuki

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Our previous study demonstrated that CD8⁺ T cells remove cysts of Toxoplasma gondii from the brain through perforin-mediated mechanisms. We here show that a transfer of CD8⁺ immune T cells primed with a type II or a type III strain of T. gondii both efficiently removed cysts of a type II strain from infected SCID mice, although the former tended to be slightly more efficient than the latter. Similarly, a transfer of type II-primed CD8⁺ T cells removed cysts of a type III strain. Therefore, CD8⁺ T cells are capable of removing T. gondii cysts by recognizing epitopes commonly expressed in types II and III strains or cross-reactive between these two genotypes.

Original language	English
Pages (from-to)	517-522
Number of pages	6
Journal	Microbes and Infection
Volume	18
Issue number	7-8
DOIs	https://doi.org/10.1016/j.micinf.2016.03.013
State	Published - Jul 1 2016

Bibliographical note

Publisher Copyright:
© 2016

Funding

The studies are supported in part by NIH grants ( AI095032 , AI073576 , and AI078756 ) (Y.S.). This work was also supported, in part, by the Intramural Research Program of the National Institutes of Health, NIAID (M.E.G.) . M.E.G. is a Scholar of the Canadian Institute for Advanced Research (CIFAR) Integrated Microbial Biodiversity program.

Funders

Funder number

National Institutes of Health (NIH)

AI078756, AI073576

National Institute of Allergy and Infectious F32-AI286447 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI168214 Jason W. Rosch Diseases National Institute of Allergy and Infectious P30 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R00-AI166116 Christopher D. Radka Diseases National Institute of Allergy and Infectious T32-AI106700 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI192221 Jason W. Rosch Diseases National Inst...

ZIAAI001017, R01AI095032

Keywords

CD8 T cells
Cyst
Genotype
Perforin
Toxoplasma gondii

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.micinf.2016.03.013

Cite this

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title = "CD8+ T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite",

abstract = "Our previous study demonstrated that CD8+ T cells remove cysts of Toxoplasma gondii from the brain through perforin-mediated mechanisms. We here show that a transfer of CD8+ immune T cells primed with a type II or a type III strain of T. gondii both efficiently removed cysts of a type II strain from infected SCID mice, although the former tended to be slightly more efficient than the latter. Similarly, a transfer of type II-primed CD8+ T cells removed cysts of a type III strain. Therefore, CD8+ T cells are capable of removing T. gondii cysts by recognizing epitopes commonly expressed in types II and III strains or cross-reactive between these two genotypes.",

keywords = "CD8 T cells, Cyst, Genotype, Perforin, Toxoplasma gondii",

author = "Eri Ochiai and Qila Sa and Sara Perkins and Grigg, \{Michael E.\} and Yasuhiro Suzuki",

note = "Publisher Copyright: {\textcopyright} 2016",

year = "2016",

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doi = "10.1016/j.micinf.2016.03.013",

language = "English",

volume = "18",

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CD8⁺ T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite. / Ochiai, Eri; Sa, Qila; Perkins, Sara et al.
In: Microbes and Infection, Vol. 18, No. 7-8, 01.07.2016, p. 517-522.

Research output: Contribution to journal › Article › peer-review

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