CE-108, a new macrolide tetraene antibiotic

Francisco J. Pérez-Zúñiga, Elena M. Seco, T. Cuesta, Falco Degenhardt, Jorgen Rohr, Carlos Vallín, Yanelis Iznaga, Marta E. Pérez, Leonora González, Francisco Malpartida

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture broth of Streptomyces diastaticus 108. In addition, the strain also produces the previously described tetraene rimocidin (1) and also the aromatic polyketide oxytetracycline. Both tetraene compounds, structurally related, are produced in a ratio between 25 to 35%,(CE-108 compared to rimocidin), although it can be inverted toward CE-108 production by changing the composition of the fermentation medium. This paper deals with the characterization of the producer strain, fermentation, purification, structure determination and biological properties of the new macrolide tetraene CE-108.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalJournal of Antibiotics
Issue number3
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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