TY - JOUR
T1 - CE-108, a new macrolide tetraene antibiotic
AU - Pérez-Zúñiga, Francisco J.
AU - Seco, Elena M.
AU - Cuesta, T.
AU - Degenhardt, Falco
AU - Rohr, Jorgen
AU - Vallín, Carlos
AU - Iznaga, Yanelis
AU - Pérez, Marta E.
AU - González, Leonora
AU - Malpartida, Francisco
PY - 2004/3
Y1 - 2004/3
N2 - In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture broth of Streptomyces diastaticus 108. In addition, the strain also produces the previously described tetraene rimocidin (1) and also the aromatic polyketide oxytetracycline. Both tetraene compounds, structurally related, are produced in a ratio between 25 to 35%,(CE-108 compared to rimocidin), although it can be inverted toward CE-108 production by changing the composition of the fermentation medium. This paper deals with the characterization of the producer strain, fermentation, purification, structure determination and biological properties of the new macrolide tetraene CE-108.
AB - In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture broth of Streptomyces diastaticus 108. In addition, the strain also produces the previously described tetraene rimocidin (1) and also the aromatic polyketide oxytetracycline. Both tetraene compounds, structurally related, are produced in a ratio between 25 to 35%,(CE-108 compared to rimocidin), although it can be inverted toward CE-108 production by changing the composition of the fermentation medium. This paper deals with the characterization of the producer strain, fermentation, purification, structure determination and biological properties of the new macrolide tetraene CE-108.
UR - http://www.scopus.com/inward/record.url?scp=11144355458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144355458&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.57.197
DO - 10.7164/antibiotics.57.197
M3 - Article
C2 - 15152805
AN - SCOPUS:11144355458
SN - 0021-8820
VL - 57
SP - 197
EP - 204
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 3
ER -